Febuxostat

Details About Generic Salt ::  Febuxostat 

Main Medicine Class:: Musculoskeletal Disorders , Pain   Sub Medicine Class ::  Anti Gout Drugs

12B. ANTI-GOUT DRUGS in 12. MUSCULOSKELETAL DISORDERS & PAIN
FEBUXOSTAT
XANTHINE OXIDASE INHIBITOR | ANTI-GOUT
PK: A: >49% D: Vss: 50L M: Hepatic E: Urine & feces

Indications & Dose: GOUT PO Adult Initially 40mg OD with NSAID or colchicine for 6 month to prevent gout flare upon initiation of therapy, may increase to 80mg OD in patient who do not achieve serum uric acid level <6mg/dL after 2 wk

Contra: Concurrent use with azathioprine/mercaptopurine/theophylline

Precautions: Severe hepatic impairment

ADR: Serious: LFT abnormalities, arthralgia, ECG abnormalities, angioedema, Others: renal insufficiency, Rash, altered urine output, vomiting, weight gain/loss, abdominal discomfort, alopecia, anemia

Monitor: Signs & symptoms of MI, stroke, LFT, serum uric acid level

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