Fenofibrate

Details About Generic Salt ::  Fenofibrate 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Fluid , Electrolyte Preparations

4F. ANTI-HYPERLIPIDEMICS in 4. CARDIOVASCULAR SYSTEM
FENOFIBRATE
FIBRIC ACID DERIVATIVE | ANTI-HYPERLIPIDEMIC
PK: A: Well absorbed D: Extensive M: Hepatic/renal E: Urine, feces

Indications & Dose: HYPERTRIGLYCERIDEMIA PO Adult Micronized capsule: 43-130mg/day, Tablet: 54-160mg/day. Adjust dose at intervals of 4-8 wk Elderly Micronized capsule: 43mg/day, Tablet: 54mg/day | MIXED DYSLIPIDEMIA PO Adult Micronized capsule: 130mg/day, Tablet: 160mg/day. Adjust dose at intervals of 4-8 wk Elderly Micronized capsule: 43mg/day, Tablet: 54mg/day | PRIMARY HYPERCHOLESTEROLEMIA PO Adult Micronized capsule: 130mg/day, Tablet: 160mg/day. Adjust dose at intervals of 4-8 wk Elderly Micronized capsule: 43mg/day, Tablet: 54mg/day

Contra: Hypersensitivity, hepatic dysfunction, severe renal dysfunction, pre-existing gallbladder disease, patients with risk factors for myopathy, nephrotic syndrome, severe renal impairment

Precautions: Pancreatitis, cholelithiasis, concurrent use of warfarin, mild-to-moderate renal impairment, elderly

ADR: Serious: Arrhythmias, ventricular extrasystoles, MI, atrial fibrillation, thrombocytopenia, leukopenia, hypoglycemia, rectal hemorrhage, renal dysfunction, asthma, varicose veins, angina, HTN, hypotension, PVD, vasodilation, ECG abnormalities, conjunctivitis, abnormal vision, PUD, cholelithiasis, prostatic disorder, hyperuricemia, tachycardia, herpes infect, edema, hypersensitivity reactions, Others: weight loss/gain, phlebitis, myositis, dyspnea, rash, diaphoresis, RTI, nausea, vomiting, diarrhea, constipation, Drowsiness, dizziness, fatigue, headache, migraine, insomnia, depression, vertigo, anxiety, neuralgia

DDI: Serious Gemfibrozil increases the risk of gallstone formation, Pravastatin level is increased, Ciclosporin reduces renal function

Diet: With food

Monitor: CBC, lipid profile, LFTs

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