Flutamide

Details About Generic Salt ::  Flutamide 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
FLUTAMIDE
ANTI-ANDROGEN | ANTI-NEOPLASTIC
PK: A: Rapid & complete E: Urine

Indications & Dose: METASTATIC PROSTATE CANCER Combination therapy PO Adult 250mg q8h with luteinizing hormone releasing hormone analog, total dose 750mg/day

Contra: Severe hepatic impairment

Precautions: CVD, mild-to-moderate hepatic impairment, avoid excessive alcohol consumption

ADR: Serious: HTN, edema, blurred vision, hemolytic anemia, SLE-like syndrome, lymphoedema, hepatic injury, Others: rash, dizziness, Gynaecomastia, nausea, vomiting, diarrhea, increased appetite, insomnia, tiredness, decreased libido, gastric & chest pain

DDI: Serious Warfarin increased anticoagulant effect, Theophylline increases drug level

Monitor: LFTs

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