Fluticasone

Details About Generic Salt ::  Fluticasone 

Main Medicine Class:: Respiratory System   Sub Medicine Class ::  Drugs For Asthma,COPD,ARDS

6A. DRUGS FOR ASTHMA/COPD/ARDS in 6. RESPIRATORY SYSTEM
FLUTICASONE
CORTICOSTEROID | ANTI-ASTHMA, GLUCOCORTICOID
also comes under 2B. Corticosteroids in 2. Ear, Nose & Throat (ENT),   15A. Corticosteroids (Topical) in 15. Skin
PK: A: Rapid D: 4.2 L/kg (Vd) M: Hepatic E: Feces, urine

Indications & Dose: ASTHMA Prophylactic therapy Inh Adult Powder/aerosol: 100-250µg BID, may be increased to 1mg BID in severe conditions Child >4 yr: Initially 50-100µg BID, increased to 200µg BID if needed | Chronic/Severe Inh Adult Nebuliser: 0.5-2mg BID Child 4-16 yr: 1mg BID | ATOPIC DERMATITIS TP Adult Cream/lotion: Apply sparingly to affected area OD/BID, if no improvement within 2 wk reassess for diagnosis Child >3 month: Cream: Same as adult dose, >1 yr: Lotion: Apply sparingly to affected area OD | CHRONIC OBSTRUCTIVE PULMONARY DISEASE Inh Adult Powder/aerosol: 500µg BID | CORTICOSTEROID-RESPONSIVE DERMATOSES TP Adult Cream/lotion/ointment: Apply sparingly to affected area BID. If no improvement within 2 wk reassess for diagnosis Child >3 month: Cream: Same as adult dose | NASAL POLYPS NSL Adult 200µg instilled into each nostril OD/BID 4-6 wk | SEASONAL/PERENNIAL ALLERGIC RHINITIS/NONALLERGIC RHINITIS Symptomatic therapy Inh Adult Initially 2 sprays (100µg/spray) in each nostril OD, after first few days reduce dose to 1 spray (100µg) into each nostril OD for maintenance therapy Child >4 yr: Initially 1 spray (50µg) in each nostril OD, may increase to 2 sprays (100µg) per nostril in patients not adequately responding or those with severe symptoms, max 2 sprays in each nostril (200µg/day)

Contra: Hypersensitivity, primary treatment of status asthmaticus/acute bronchospasm, presence of acute infect, administration of live vaccines, active/doubtfully quiescent TB

Precautions: CVD, thyroid disease, hepatic/renal impairment, DM, glaucoma, cataracts, myasthenia gravis, osteoporosis, GI diseases, history of seizures, acute MI, elderly, during drug withdrawal

ADR: Serious: Cushing’s Syndrome, hypersensitivity reactions, hypopigmentation, raised IOP, reduced visual function, osteoporosis, Churg-Strauss syndrome, Others: muscle wasting & nitrogen depletion, hyperglycemia, menstrual irregularities, mental & neurological disturbances, amenorrhea, atrophy, loss of skin collagen, dryness, irritation, ulceration/perforation of nasal septum, hoarseness & candidiasis of mouth/throat, increased susceptibility to infect, delayed wound healing

DDI: Serious Ketoconazole/Itraconazole increases drug levels, HIV protease inhibitors leads to Cushing’s syndrome

Monitor: Growth, signs/symptoms of HPA axis suppression/adrenal insufficiency, eosinophilic conditions, FEV1, peak flow, and other pulmonary function tests, asthma symptom

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