Details About Generic Salt ::  Gefitinib 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
GEFITINIB
EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR | ANTI-NEOPLASTIC
PK: A: Slow (PO) D: 1400 L M: Hepatic E: Feces (86%), urine (<4%)

Indications & Dose: NON-SMALL CELL LUNG CANCER PO Adult 250mg/day

Contra: Hypersensitivity

Precautions: Hepatic impairment/hepatotoxicity, idiopathic pulmonary fibrosis, concurrent use of CYP3A4 inducers

ADR: Serious: CNS hemorrhage, peripheral edema, conjunctivitis, hematuria, ocular hemorrhage, TEN, angioedema, interstitial lung disease, interstitial pneumonia, Others: epistaxis, erythema multiforme, urticaria, corneal erosion/ulcer, rash, diarrhea, nausea, vomiting, pruritus, anorexia, weight loss, mouth ulceration, weakness, amblyopia, acne, dry skin, paronychia, dyspnea

DDI: Serious Carbamazepine/Barbiturates/Phenytoin decreases drug levels & its efficacy, Warfarin effects increases, Itraconazole/HIV protease inhibitors/Ketoconazole/Macrolides/Voriconazole raises drug levels & might increases its efficacy

Diet: With/without food

Monitor: LFTs, INR/PT, pulmonary symptoms

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