Gemifloxacin

Details About Generic Salt ::  Gemifloxacin 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Quinolones

13G. QUINOLONES in 13. ANTI-INFECTIVES
GEMIFLOXACIN
QUINOLONE | ANTI-INFECTIVE (BROAD-SPECTRUM)
PK: A: Well absorbed D: 4.2 L/kg (Vdss) M: Hepatic E: Feces (61%), urine (36%)

Indications & Dose: BACTERIAL EXACERBATIONS OF CHRONIC BRONCHITIS Acute PO Adult 320mg OD 5 days | COMMUNITY-ACQUIRED PNEUMONIA PO Adult 320mg OD 1 wk

Contra: Hypersensitivity, patients receiving Class Ia & Class III antiarrhythmics

Precautions: History of QTc prolongation, known or suspected CNS disorder, renal impairment, G6PD deficiency, myasthenia gravis, CVD, RA, uncorrected hypokalemia, hypomagnesemia, elderly

ADR: Serious: Blood disorders, increased GGT , transaminases, CPK, peripheral neuropathy, hypoglycemia, prolong QT interval, SJS, TEN, anaphylaxis, Others: Phototoxicity, fungal/bacterial superinfect, headache, dizziness, rash, diarrhea, nausea, vomiting, abdominal pain

DDI: Serious Sucralfate reduces drug absorption, Calcium compounds/Antacids reduces drug bioavailability

Diet: With/without food, milk or calcium supplements

Monitor: WBC, signs & symptoms of infect, renal function

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