Glibenclamide (Glyburide)

Details About Generic Salt ::  Glibenclamide (Glyburide) 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
GLIBENCLAMIDE (GLYBURIDE)
SULFONYLUREA | ANTI-DIABETIC
PK: A: Rapid(1h) D: 9-10 L M: Hepatic E: Feces(50%) & urine(50%)

Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult Initially 2.5-5mg/day (1.25mg/day in patients sensitive to hypoglycemic drugs), increase by no more than 2.5mg/day at weekly intervals based on response, MD 1.25-20mg/day single or divided doses max 20mg/day

Contra: Hypersensitivity, type 1 DM, concomitant use with bosentan, DKA

Precautions: Renal/hepatic impairment, elderly, substitute insulin during infect, substitute insulin during surgery

ADR: Serious: Angioedema, maculopapular eruptions, hypoglycemia, hyponatremia, thrombocytopenia, hepatitis, Others: Dizziness, headache, anorexia, constipation, diarrhea, epigastric fullness, nausea, paresthesia, myalgia

DDI: Serious Fibrates/Chloroquine/Hydroxy chloroquine/Mefloquine/Phenylbutazone/Quinine/Thiazides causes hypoglycemia, Rifampicin decreases drug effects, Orlistat increases drug effects, Bosentan increases risk of liver toxicity, Clarithromycin/Ciprofloxacin/Erythromycin/Fluconazole/Fluvoxamine/Levofloxacin/Miconazole/Norfloxacin results in hypoglycemia

Diet: With food

Monitor: Blood glucose & HbA1c

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