Glipizide

Details About Generic Salt ::  Glipizide 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
GLIPIZIDE
SULFONYLUREA | ANTI-DIABETIC
PK: A: Rapid D: 10-11 L M: Hepatic E: Urine 60% to 80%) & feces (11%)

Indications & Dose: TYPE 2 DIABETES MELLITUS Chronic PO Adult Initially 2.5–5mg/day, up to 15mg may be given as single dose, max 20mg/day

Contra: Hypersensitivity, type 1 DM, DKA

Precautions: Elderly, hepatic/renal impairment

ADR: Serious: Hypoglycemia, hyponatremia, thrombocytopenia, hepatitis, maculopapular eruptions, morbilliform eruptions, eczema, Others: dizziness, headache, epigastric fullness, nausea, paresthesia, myalgia, constipation, nervousness, myalgia, insomnia

DDI: Serious Fluconazole causes hypoglycemic coma, Cyclosporine levels are increased by two folds, Cholestyramine reduces drug absorption, Rifampicin reduces drug effects, Erythromycin/Clarithromycin/Gatifloxacin/Heparin results in hypoglycemia

Diet: Before food (30 mins)

Monitor: Hypoglycemia, blood glucose & HbA1c

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