Griseofulvin

Details About Generic Salt ::  Griseofulvin 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Anti Fungals

13I. ANTI-FUNGALS in 13. ANTI-INFECTIVES
GRISEOFULVIN
ANTI-FUNGAL
PK: A: Variable & incomplete M: Liver E: Feces, urine (<1%) & sweat

Indications & Dose: TINEA CAPITIS PO Adult Ultramicrosize: 330/375mg OD, Microsize: 500mg/day 8-12 wk Child >2 yr: Ultramicrosize: 5-15mg/kg/day in 1-2 divided doses, max 750mg/day, Microsize: 10-20mg/kg/day 1-2 divided doses | TINEA CORPORIS PO Adult Ultramicrosize: 330/375mg OD, Microsize: 500mg/day 2-4 wk | TINEA CRURIS PO Adult Ultramicrosize: 330/375mg OD, Microsize: 500mg/day | TINEA PEDIS PO Adult Ultramicrosize: 660/750mg OD, Microsize: 1g/day 4-8 wk | TINEA UNGUIUM PO Adult Ultramicrosize: 660/750mg OD, Microsize: 1g/day 3-6 months/longer

Contra: Severe liver disease, men should not father children within 6 months of treatment, porphyria, systemic lupus erythematosus

Precautions: Pre-existing hepatic insufficiency, blood disorders

ADR: Serious: SLE, TEN, peripheral neuropathy, hepatotoxicity, impaired coordination, Others: sleep disturbances, photosensitivity, confusion, Headache, nausea, vomiting, diarrhea, rash, dizziness, fatigue, leukopenia

DDI: Serious Hormonal Contraceptives leads to contraceptive failure or intermenstrual bleeding/amenorrhea, Phenobarbital reduces/abolishes effect of drug

Diet: With fatty meal