Hydroxyzine

Details About Generic Salt ::  Hydroxyzine 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anxiolytics

1B. ANXIOLYTICS in 1. NERVOUS SYSTEM
HYDROXYZINE
ANTI-HISTAMINE | ANTI-PRURTIC, ANXIOLYTIC, SEDATIVE & HYPNOTIC
also comes under 15L. Anti-Pruritic Drugs in 15. Skin,  1A. Sedatives & Hypnotics in 1. Nervous System
PK: A: Rapid

Indications & Dose: ANXIETY Short-term therapy PO Adult 50-100mg QID Child <6 yr: 50mg/day in divided doses, >6 yr: 50-100mg/day in divided doses | Short-term therapy IM Adult Initially 50-100mg, then q4-6h as needed | PREOPERATIVE SEDATION PO Adult 50-100mg Child 0.6mg/kg/dose | IM Adult 25-100mg Child 0.5-1mg/kg/dose | PRURITUS PO Adult 25mg TID/QID Child 6 month-6 yr: Initially 5-15mg HS, increased to 50mg/day in 3-4 divided doses if required, 6-12 yr: Initially 15-25mg HS, increased to 50-100mg/day in 3-4divided doses if required, 12-18 yr: Initially 25mg HS, increased to 50-100mg/day in 3-4divided doses if required

Contra: Hypersensitivity, Sc/intra-arterial/IV administration

Precautions: Narrow-angle glaucoma, prostatic hyperplasia and/or urinary stricture, asthma/COPD, bladder neck obstruction, elderly

ADR: Serious: hypersensitivity reaction, Others: pain/abscess at IM Inj site, drowsiness, agitation, dizziness, headache, asthenia, ataxia, nausea, constipation, dry mouth, urinary retention, wheezing, flushing, bitter taste

DDI: Serious Alcohol increases drowsiness effect of drug, Cimetidine moderately raises drug levels

Monitor: Adverse effects, LFTs

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