Hyperbilirubinemia Classification Types Symptoms Examination

Hyperbilirubinemia Classification Types Symptoms Examination

Hyperbilirubinemia

Hyperbilirubinemias are conditions where the serum bilirubin is high.

An excessive amount of bilirubin in the blood; the condition is seen in any illness causing jaundiceCauses of jaundice with diagnosis and bio markers. Read more ... », including diseases in which the biliary tree is obstructed, and those in which blood formation is ineffective

Pediatrics:In newborns, high bilirubin levels due to rapid destruction of red blood cells may be caused by maternal factors such as Rh or ABO incompatibility, prenatal use of certain therapeutic drugs, or intrauterine viral infection.

HISTORY AND PHYSICAL EXAMINATION —

• Multiple clues to the etiology can be obtained from the history,
• which should include the following information:
• Medications Use of drugs or herbal medications
• Use of alcohol Hepatitis risk factors
• History of abdominal operations, including gallbladder surgery
• History of inherited disorders including liver diseases and hemolytic disordersCauses of jaundice with diagnosis and bio markers. Read more ... »
• HIVAIDS Acquired Immunodeficiency Syndrome Diagnosis Signs and Symptoms with Treatment. Read more ... » status
• Travel history Exposure to toxic substances

Classification of jaundice according to type of bile pigment and mechanism

• Unconjugated hyperbilirubinemia

  • Increased bilirubin production*
  • Extravascular hemolysis
  • Extravasation of blood into tissues
  • Intravascular hemolysis
  • Dyserythropoiesis
  • Impaired hepatic bilirubin uptake
  • Congestive heartFirst degree AV block,Second degree AV block (Mobitz type I,Mobitz type Il),Third degree AV block. Read more ... » failure
  • Portosystemic shunts
  • Some patients with Gilbert’s syndromeMetabolic,Insulin Resistance Syndrome X Causes Symptoms. Read more ... »
  • Certain drugs – rifampin, probenecid flavaspadic acid, bunamiodyl
  • Impaired bilirubin conjugation
  • Crigler-Najjar syndrome type I and II
  • Gilbert’s syndrome
  • Neonates
  • HyperthyroidismThyroid Disorders Examination and Laboratory tests. Read more ... »
  • Ethinyl estradiol
  • Liver diseases – chronicChronic Hepatitis Classification viral hepatitis Clinical features and Treatment. Read more ... » persistent hepatitis, advanced cirrhosis, Wilson’s diseaseVisada Depression Ayurveda and Modern. Read more ... »

• Conjugated hyperbilirubinemia

  • Extrahepatic cholestasisToxic Hepatitis and Drug Induced Hepatitis Diagnosis and Treatment. Read more ... » (biliary obstruction)
  • Choledocholithiasis
  • Intrinsic and extrinsic tumors – eg, cholangiocarcinoma
  • Primary sclerosing cholangitis
  • AIDS cholangiopathy
  • AcuteVisada Depression Ayurveda and Modern. Read more ... » and chronic pancreatitis
  • Strictures after invasive procedures
  • Certain parasitic infections – eg, Ascaris lumbricoides, liver flukes
  • Intrahepatic cholestasis
  • Viral hepatitis
  • Alcoholic hepatitis
  • Nonalcoholic steatohepatitis
  • Primary biliary cirrhosisBiliary Cirrhosis (Primary and Secondary) Symptoms Diagnosis and Treatment. Read more ... »
  • Drugs and toxins – eg, alkylated steroids, chlorpromazine, herbal medications (eg, Jamaican bush tea), arsenic
  • SepsisSepsis (Septic Shock) Definition Diagnosis and Pathophysiology. Read more ... » and hypoperfusion states
  • Infiltrative diseases – eg, amyloidosisAmyloidosis Symptoms Diagnosis Prognosis and Treatment. Read more ... », lymphoma, sarcoidosisSarcoidosis Causes Diagnosis Symptoms and Treatment. Read more ... », tuberculosis
  • Total parenteral nutrition
  • Postoperative patient
  • Following organ transplantation
  • Hepatic crisis in sickle cellHemoglobinopathies Sickle cell Thalssemia Diagnosis Treatment. Read more ... » disease
  • Pregnancy
  • End-stage liver disease
  • Hepatocellular injury

* Serum bilirubin concentration usually less than 4 mg/dL (68 mmol/L) in the absence of underlying liver disease

Hemolytic jaundice

• Due to excess hemolysis there is unconjugated hy­perbilirubinemia.
• Usually the serum bilirubin is less than 4 mgjdl.
• Common causesVisada Depression Ayurveda and Modern. Read more ... »: viral hepatitis, cirrhosis, cholelithiasis, tumors (liver, pancreas), hemolytic anemia, toxins, inherited disorders

Ineffective erythropoiesis

• In Thalassemia major, megaloblastic anaemia, con­genital erythropoietic porphyriaPorphyrias Inherited disorders Causes Classifications Diagnosis and Treatment. Read more ... », lead poisoning, and dyserythropoietic anaemias, bilirubin production is increased resulting in unconjugated bilirubinemia.
• In large hemat mas, massive infiuctions There may be unconjugated hyperbilirubinemia.
• In drugVisada Depression Ayurveda and Modern. Read more ... »-induced cholecystographic contrast agent and novobiocin-induced jaundice there is unconjugated bilirubinemia.

Physiological Neonatal Jaundice

• Unconjugated hyperbilirubinemia is seen between 2^nd and 5^th day after birth. Jaundice may be up to 10 mgj dl. .~

Crigler-Najjar Syndrome – Type I

• There is defect in glucuronide conjugation of bilirubin and other substrates.
• There is unconjugated hyperbilirubinemia up to 45 mgjdl, with AST and ALT normal and no hemolysis. This is a rare disorderSleep Disorders Types Diagnose Of Sleep Disorders. Read more ... ». There is often death due to kernicterus (bilirubin encephalopathy).

Cngler Najjar Syndrome – Typ 11

• In this also there is defective conjugation of bilirubin but bilirubin concentration is less than in eN-I. Marked unconjugated hyperbilirubinemia, with normal AST and ALT not associated with kernicterus (bilirubin encephalopathy) .

Gilbert’s Syndrome

• In this syndrome there is defect in bilirubin uptake and conjugation.
• There is mild unconjugated hyperbilirubinemia, se­rum bilirubin is less than 3 mgjdl.
• AST and ALT are normal.
• Gilbert syndrome is common with prevalence more than 8%, with male: female ratio 5 : 1.

Dubio Johnson Syndrome

• There is defective hepatic excretion of bilirubin.
• There is low grade conjugated hyperbilirubinemia. It is rare.
• ALT and AST are normal.

Rotor syndrome

• This is autosomal recessive disorder, with conjugated bilirubinemia, no jaundice and very rare.
• It is due to defective hepatobiliary function.
• The gall bladder is usually visualized on oral chole­cystography whereas in DJS the gall bladder is not visualized.

Byler disease

• Presents in infancy with cholestatic jaundice.