Ifosfamide

Details About Generic Salt ::  Ifosfamide 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
IFOSFAMIDE
ALKYLATING AGENT, NITROGEN MUSTARD | ANTI-NEOPLASTIC
PK: D: 5.7-49 L (Vd) M: Hepatic E: urine (as unchanged drug & metabolites)

Indications & Dose: TESTICULAR CANCER IV Adult 1.2g/m2/day as inf over 30min to several h for 5 days q3wk

Contra: Hypersensitivity, severe bone marrow depression

Precautions: Patients with compromised bone marrow reserve, renal impairment

ADR: Serious: CNS toxicity/encephalopathy, myelosuppression, thrombocytopenia, leukopenia, hematuria, CRF, cardiotoxicity, nephrotoxicity, secondary neoplasms, liver dysfunction, Others: hyperpigmentation, allergic reaction, diarrhea, fanconi syndrome, fatigue, infect, drowsiness, confusion, ataxia, hallucinations, depressive psychosis, dizziness, phlebitis, metabolic acidosis, nausea/vomiting, fever

DDI: Serious Warfarin effects increases, Phenytoin increases drug metabolism, Amphotericin-B increases risk of renal impairment, Cisplatin increases risk of renal toxicity, Rifampicin induces drug metabolism, Ketoconazole inhibits drug metabolism leads to decreases its efficacy, Irinotecan level reduced, Phenobarbital reduces drug levels

Monitor: CBC, Hb, platelet count, urine output, urinalysis, LFTs, renal function tests