Iloperidone

Details About Generic Salt ::  Iloperidone 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

1E. ANTI-PSYCHOTICS in 1. NERVOUS SYSTEM
ILOPERIDONE
D2/5-HT2A ANTAGONIST | ANTI-PSYCHOTIC
PK: A: Well absorbed D: Vd: 1340-2800 L M: Hepatic E: urine, feces

Indications & Dose: SCHIZOPHRENIA PO Adult Initially 1mg BID, max 24mg/day. May be increase the dose in increments of 2mg q 24hrs on day 2-7

Contra: Hypersensitivity, drugs that prolong Qtc interval

Precautions: hepatic impairment, cardiovascular disease, DM/other disorders of glucose regulation, history of seizures

ADR: Serious: extrapyramidal symptoms, arthralgia, stiffness, muscle spasm, myalgia, blurred vision, conjunctivitis, tachycardia, orthostatic hypotension, URTI, erectile dysfunction, ejaculation failure, Others: fatigue, nasal congestion, tremor, nausea, weight gain, abdominal discomfort, xerostomia

DDI: Others Chloroquine/Alfuzosin/Ciprofloxacin/Lithium increases iloperidone levels/effects, MAOIs/Amphetamine levels decreases, CNS Depressants/Alcohol/Drugs that prolong QT interval/Methylphenidate/Quinine/Tetrabenazine levels increases

Diet: With/without food

Monitor: Vital signs, fasting blood glucose, CBC,orthostatic blood pressure changes, se k & Mg levels, signs & symptoms of cardiac arrhythmia & hyperglycemia

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