Imipenem , Cilastatin

Details About Generic Salt ::  Imipenem , Cilastatin 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13D. OTHER BETA LACTAMS in 13. ANTI-INFECTIVES
IMIPENEM + CILASTATIN
CARBAPENEM ANTIBIOTIC | ANTI-INFECTIVE
PK: A: Imipenem:60-75%; cilastatin:95-100% D: Extensively M: Renal E: Urine

Indications & Dose: CYSTIC FIBROSIS IV Child up to 90mg/kg/day | INTRA-ABDOMINAL INFECT Severe IV Adult 500mg q6h or 1g q8h for 4-7 days | Mild IV Adult 250-500mg q6h | LOWER RESPIRATORY TRACT INFECT Mild-to-moderate IM Adult 500-750mg q12h | PSEUDOMONAS INFECT IV Adult 500mg q6h, higher doses may be required based on organism sensitivity | SEVERE INFECT IV Adult Fully susceptible organisms: 500mg q6h, Moderately susceptible organisms: 1g q6-8h | SKIN/SKIN STRUCTURE INFECT Mild-to-moderate IM Adult 500-750mg q12h | SUSCEPTIBLE INFECT IV Adult 250-1000mg q6-8h, max 4g/day Child <1 wk: 25mg/kg q12h, 1-4 wk: 25mg/kg q8h, 4 wk-3 months: 25mg/kg q6h, >3 months & <40kg: 15-25mg/kg q6h, max 2g/day, >40kg: Same as adult dose | Mild-to-moderate IM Adult 500mg or 750mg q12h | URINARY TRACT INFECT Uncomplicated IV Adult 250mg q6h | Complicated IV Adult 500mg q6h

Contra: Hypersensitivity, severe shock /heart block, patients with clcr <5 ml/min/1.73 m2, renal impairment

Precautions: CNS disorders, elderly

ADR: Serious: thrombophlebitis, tachycardia, seizure, Others: oliguria, rash, pain at Inj site, nausea, diarrhea, vomiting

DDI: Serious Pyridostigmine causes aggravation of myasthenic symptoms, Ciclosporin increases CNS adverse effects, Valproic acid/Theophylline leads to seizures, Haloperidol leads to transient hypotension, Ganciclovir results in generalized seizures, Vaccine, BCG therapeutic effect diminishes

Diet:

Monitor: Periodic RFT, LFT & hematologic function test, signs of anaphylaxis during first dose

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