Indapamide

Details About Generic Salt ::  Indapamide 

Main Medicine Class:: Genito Urinary System   Sub Medicine Class ::  Diuretics

4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM
INDAPAMIDE
THIAZIDE DIURETIC | DIURETIC, ANTI-HYPERTENSIVE
also comes under 10A. Diuretics in 10. Genito-Urinary System,  
PK: A: Well absorbed M: Hepatic E: Urine, feces

Indications & Dose: EDEMA IN HEART FAILURE/NEPHROTIC SYNDROME PO Adult 2.5-5mg/day | HYPERTENSION Mild-to-moderate PO Adult 1.25mg in morning, increase by 1.25-2.5mg to 5mg/day. Reduce dose if no response & add another drug

Contra: Hypersensitivity, anuria, renal decompensation, severe hepatic impairment, Addison’s disease, pre-existing hypercalcemia

Precautions: DM, gout, renal/hepatic impairment, hypercalcemia, hypercholesterolemia, hypokalemia, parathyroid disease, SLE, existing fluid & electrolyte disturbances, elder, severe HF who are very edematous

ADR: Serious: Arrhythmias, hypochloremic alkalosis, necrotizing vasculitis, premature ventricular contractions, blurred vision, decreased electrolyte, muscle cramps & spasms, orthostatic hypotension, Others: palpitations, rash, weight loss, nausea, vomiting, diarrhea, constipation, bloating, epigastric distress, abdominal pain/cramps, dry mouth, anorexia, nocturia/polyuria/glycosuria, erectile dysfunction, gout, hyperglycemia, dizziness, light-headedness, restlessness, insomnia, lethargy, fatigue, drowsiness, asthenia, depression, anxiety, nervousness, paresthesia

DDI: Serious Lithium toxicity occurs

Diet: With food

Monitor: BP(both standing & sitting/supine), serum electrolytes, renal function, weight, fluid intake & output

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