Irbesartan

Details About Generic Salt ::  Irbesartan 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Hypertensives

4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM
IRBESARTAN
ANGIOTENSIN II RECEPTOR ANTAGONIST | ANTI-HYPERTENSIVE
PK: A: Rapid D: 53-93 L (Vd) M: Hepatic E: Feces (80%), urine (20%)

Indications & Dose: DIABETIC NEPHROPATHY PO Adult 300mg/day | HYPERTENSION PO Adult 150mg/day, max 300mg/day Child >6-12 yr: 75mg/day, max 150mg/day, >13 yr: Same as adult dose | HYPERTENSIVE NEPHROPATHY PO Adult 300mg/day

Contra: Hypersensitivity

Precautions: Hypovolemia, aortic/mitral stenosis, unilateral/bilateral renal artery stenosis, renal impairment, elderly

ADR: Serious: Orthostatic hypotension, renal failure, hyperkalemia, myalgia, Others: GI disturbances, fatigue, neutropenia, rash, urticaria, URTI, diarrhea, dyspepsia, fatigue, dizziness

DDI: Serious Aliskiren leads to greater reduction in BP, Lithium leads to lithium toxicity, Antacids reduces drug levels, Fluconazole reduces drug metabolism

Diet: With/without food

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