Isosorbide Mononitrate

Details About Generic Salt ::  Isosorbide Mononitrate 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

4C. ANTI-ANGINALS in 4. CARDIOVASCULAR SYSTEM
ISOSORBIDE MONONITRATE
VASODILATOR | ANTI-ANGINAL
PK: A: Rapid D: 2-4 L/kg (Vd) M: Hepatic E: Urine & feces

Indications & Dose: ANGINA PECTORIS PO Adult Regular release tablet: Initially 5-20mg BID (7h interval between 2 doses). When 5mg BID dose is used, then titrate up to 10mg BID for first 2-3days. ER: Initially 30-60mg OD in the morning & titrate upward as needed, giving at least 3 days between increases, max 240mg/day as single dose Elderly Start with low dose

Contra: Hypersensitivity, concurrent use with PDE-5 inhibitors, severe hypotension, hypovolemia, marked anemia, HF due to obstruction, raised intracranial pressure due to head trauma/cerebral hemorrhage, angle-closure glaucoma

Precautions: Head trauma, elderly, severe renal/hepatic impairment, hypothyroidism, malnutrition, hypothermia, metalcontaining TD patches should be removed before cardioversion/diathermy

ADR: Serious: Hypotension, postural hypotension, syncope, flushing, tachycardia, vomiting/restlessness/blurred vision, impairment of respiration, bradycardia, Others: contact dermatitis, local irritation & erythema, dizziness, Headache

DDI: Serious Phosphodiesterase type-5 inhibitors potentiate hypotensive effects of drug

Monitor: BP, HR

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