Details About Generic Salt ::  Isotretinoin 

Main Medicine Class:: Skin   Sub Medicine Class ::  Drugs for Acne

15K. DRUGS FOR ACNE in 15. SKIN
ISOTRETINOIN
RETINOID | ANTI-ACNE
PK: M: Hepatic E: Urine (as metabolites) & feces (as unchanged drug)

Indications & Dose: ACNE TP Adult Gel (0.05%): Apply sparingly once/twice daily, therapeutic response may not be evident for 6-8 wk | RECALCITRANT NODULAR ACNE PO Adult 0.5-1mg/kg/day in 2 divided doses (dosages as low as 0.05mg/kg/day have been reported to be beneficial) for 15-20 wk or until the total cyst count decreases by 70%. Adjust dose up to 2mg/kg/day in severe disease/scarring/if trunk is involved. Second course may be initiated after a period of > 2 months off therapy Child 12-17 yr: Same as adult dose

Contra: Hypersensitivity, sensitivity to parabens/vitamin A/other retinoids, hepatic impairment, hyperlipidemias, hypervitaminosis A, concomitant use of tetracyclines, long-term use

Precautions: Should not donate blood during/1 month after stopping therapy, renal impairment, history of depression, affect the performance of skilled tasks such as driving, children <12 yr, avoid excessive exposure to sunlight & UV light, avoid contact with eyes/mouth/other mucous surfaces, should not be applied to eczematous/sunburnt/abraded skin/other topical treatment, especially with keratolytics

ADR: Serious: Chest pain, edema, flushing, palpitation, stroke, tachycardia, vascular thrombotic disease, arthritis, cataracts, color vision disorder, tinnitus, glomerulonephritis, bronchospasm, respiratory infect, allergic reactions, colitis & esophagitis, IBD, pancreatitis, blood disorders, hepatitis, TC level increased, Others: blood glucose increased, arthralgia, aggressive behavior, depression, dizziness, drowsiness, emotional instability, headache, insomnia, lethargy, malaise, paresthesia, seizure, suicidal ideation, alopecia, cutaneous allergic reactions, fragility of skin, hirsutism, rash

DDI: Serious Tetracyclines causes pseudotumour cerebri (benign intracranial HTN), Ritonavir/Indinavir leads to drug toxicity & reduced plasma levels of retinoic acid, Vit A over dosage my occur, Alcohol reduces drug effect markedly

Diet: With food

Monitor: CBC with DC & platelet count, ESR, glucose, CPK, signs of depression, mood alteration, psychosis, aggression, severe skin reactions, pregnancy test, LFT, Lipid profile

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.