LABORATORY TESTS FOR ADRENAL FUNCTIONS

LABORATORY TESTS FOR ADRENAL FUNCTION

  • · Tests of pituitary adrenal responsiveness.
  • · Suppression tests -are measurement of target hormone response after suppression of its tropic hormone.
  • · Stimulation tests
  • · Plasma ‘Levels of ACTH and angiotensin II.
  • · Measurement of urinary free cortisol
  • · Measurement of urinary creatinine
  • · Measurement of plasma and urinary level of ste­roids.
  • · Measurement of peripheral plasma renin activ­ity (PRA)
  • · Measurement of DHEA (Dehydroepiandrosterone)
  • · Measurement of cortisol and aldosterone.
  • – Tests of pituitary adrenal suppressibility
  • – Tests of mineralocorticoid suppressibility
  • – Test of mineralocorticoid reserve
  • – Test of glucocorticoid reserve- Rapid ACTH stimulation test
  • Seeking a treatable cause of the primary disorder (eg, histoplasmosis involving the adrenal glands or a pituitary adenoma compromising normal pituitary function)
  • evaluating mineralocorticoid secretion in patients without ACTH deficiency
  • Determining whether the cortisol deficiency is dependent on or independent of ACTH deficiency
  • Demonstrating inappropriately low cortisol secretion

  Adrenal Gland

HYPERFUNCTION OF ADRENAL CORTEX

  • Excess of cortisol causes Cushing’s syndrome. Excess of aldosterone causes Aldosteronism.
  • Excess of adrenal androgen causes Virilism (male fea­tures in females).

Diagnostic approach to suspected adrenal insufficiency

  Diagnostic approach to suspected adrenal insufficiency

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