Details About Generic Salt ::  Letrozole 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
LETROZOLE
AROMATASE INHIBITOR | ANTI-NEOPLASTIC
PK: A: Rapid & well absorbed D: ~1.9 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: ADVANCED BREAST CANCER IN POSTMENOPAUSAL WOMEN PO Adult 2.5mg OD continue until tumor progression for first or second line treatment | EARLY BREAST CANCER IN POSTMENOPAUSAL WOMEN PO Adult 2.5mg OD 5yr (optimal duration unknown) or continue until tumor progression as extended adjuvant therapy given after 5yr of tamoxifen, discontinue at relapse | Adjuvant therapy PO Adult 2.5mg OD 5yr (optimal duration unknown), discontinue at relapse

Contra: Anticipated pregnancy, hypersensitivity

Precautions: Hepatic impairment, osteoporosis

ADR: Serious: Edema, hypercholesterolemia, arthritis, BMD decreased/osteoporosis, dyspnea, chest pain, HTN, CVA, hypercalcemia, UTI, vaginal hemorrhage, cataract, secondary malignancy, Others: infect, myalgia, diarrhea, vomiting, weight loss, insomnia, depression, rash, diaphoresis, hot flashes, nausea, weight gain, constipation, weakness, headache, dizziness, fatigue

Diet: With/without food

Monitor: CBC, TFT, serum electrolytes, TC, transaminases & creatinine, BP, bone density

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