Levodopa , Carbidopa

Details About Generic Salt ::  Levodopa , Carbidopa 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Drugs for Neurodegenerative Disorders

1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM
LEVODOPA + CARBIDOPA
DOPAMINE AGONIST | ANTI-PARKINSONIAN
PK: D: 0.9-1.6 L/kg E: Urine

Indications & Dose: PARKINSON’S DISEASE PO Adult Initially levodopa 100mg & carbidopa 10mg BID, increase levodopa by 100mg, max 1.5g & carbidopa 10mg q few days as needed

Contra: Severe psychiatric illness, abrupt withdrawal/rapid dose increment, concurrent use of MAOIs, angle closure glaucoma, confirmed/suspected malignant melanoma

Precautions: Pulmonary disease, PUD, CVD, DM, osteomalacia, open-angle glaucoma, history of melanoma, psychiatric illness, elderly

ADR: Serious: postural hypotension, tachycardia, arrhythmias, flushing, GI bleeding, peripheral neuropathy, liver enzyme changes, psychiatric symptoms, dyskinesia, painful dystonic spasms, NMS, hypersensitivity, Others: delusions, nausea, anorexia, vomiting, taste disturbances, rash, reddish discoloration of body fluids, insomnia, headache, drowsiness, sudden onset of sleep, confusion, vivid dreams, dizziness

Diet: With food

Monitor: LFTs, CBC, psychiatric, cardiovascular, renal function

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