LODIRIC 10 100MG

The Brand Name LODIRIC Has Generic Salt :: Allopurinol 

LODIRIC  Is From Company Novartis Priced :: Rs. 145

LODIRIC have Allopurinol is comes under Sub class Anti Gout Drugs of  Main Class Musculoskeletal Disorders , Pain

Main Medicine Class:: Musculoskeletal Disorders , Pain  Sub Medicine Class :: Anti Gout Drugs 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Allopurinol  TAB  Rs. 145  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 LODIRIC  Novartis  100MG  10 Rs. 145

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Novartis :: LODIRIC  Allopurinol  Musculoskeletal Disorders , Pain Anti Gout Drugs

Indications for Drugs ::

Hyperuricaemia, Uric acid nephropathy, Cancer therapy-induced hyperuricaemia, Gout, Recurrent renal stones

Drug Dose ::

Adult: PO Gout; Hyperuricaemia Initial: 100 mg/day, may adjust dose according to response. Max: 800 mg/day. Prevention of hyperuricaemia associated w/ chemotherapy treatment or enzyme disorders 600-800 mg/day, starting 2-3 days before cancer treatment. Renal impairment: Haemodialysis: Administer dose after session or administer 50% supplemental dose. CrCl (ml/min) 10-20 200 mg daily. <3 100 mg daily at extended intervals. 3-10 daily. hepatic impairment: dose reduction may be needed. monitor liver function regularly. Contraindication ::

Hypersensitivity; acute attack of gout.

Drug Precautions ::

Ensure adequate fluid intake. Prophylactically with an anti-inflammatory or colchicine for at least 1 mth. Withdraw immediately when sensitivity (skin rash, etc) appears. Pregnancy, lactation. Hepatic and renal impairment.

Drug Side Effects ::

Rash; alopoecia; GI disorders, taste disturbances, nausea, vomiting, abdominal pain, diarrhoea; paraesthesia, peripheral neuropathy, vertigo, headache, hepatic necrosis, drowsiness, neuritis, arthralgia; hypertension. Potentially Fatal: Stevens-Jonhson and/or Lyell’s Syndrome (urticaria, fever, lymphadenopathy, arthralgia). Occasionally, thrombocytopaenia, agranulocytosis and aplastic anaemia.

Pregnancy category ::
Pregnancy category

3

Drug Mode of Action ::  

Allopurinol is an inhibitor of the enzyme xanthine oxidase which converts hypoxanthine to xanthine then uric acid. The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid, there is no risk of nephrolithiasis.

Drug Interactions ::

May inhibit the metabolism of mercaptopurine and azathioprine; reduce dose of mercaptopurine and azathioprine when given w/ allopurinol. May increase effect of warfarin and other coumarin anticoagulants. Increased excretion of the oxipurinol (metabolite) w/ salicylates or uricosuric agents. Increased toxicity w/ thiazide diuretics, some antibacterials, other antineoplastics, ciclosporin, some sulfonylurea antidiabetics, theophylline and vidarabine.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.
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