Lomustine

Details About Generic Salt ::  Lomustine 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
LOMUSTINE
ALKYLATING DRUG (NITROSOUREA) | ANTI-NEOPLASTIC
PK: A: Complete M: Hepatic E: Urine (~50%), feces (<5%), expired air (<10%)

Indications & Dose: BRAIN TUMORS/HODGKIN’S DISEASE PO Adult 130mg/m2 as single dose q6 wk. Do not repeat dose until platelet count is >100, 000/mm3 & WBC count >4, 000/mm3. In individuals with bone marrow suppression, reduce the initial dosage to 100mg/m2 given q6wk

Contra: Hypersensitivity

Precautions: Renal/hepatic impairment, bone marrow suppression

ADR: Serious: Myelosuppression, acute leukemia, alkaline phosphatase increased, blood disorders, bilirubin increased, pulmonary fibrosis, renal failure, optic atrophy, pulmonary infiltrates, blindness, dysarthria, bone marrow dysplasia, Others: nausea & vomiting, alopecia, lethargy, ataxia, azotemia, disorientation, stomatitis, visual disturbances

DDI: Serious Theophylline causes thrombocytopenia & bleeding, Cimetidine increases bone marrow depressant effects

Diet: With fluids on an empty stomach/no food/drink for 2h after administration

Monitor: CBC with differential & platelet count, hepatic & renal function tests (periodic), pulmonary function tests

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