Lovastatin

Details About Generic Salt ::  Lovastatin 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Fluid , Electrolyte Preparations

4F. ANTI-HYPERLIPIDEMICS in 4. CARDIOVASCULAR SYSTEM
LOVASTATIN
HMG-COA REDUCTASE INHIBITOR | ANTI-HYPERLIPIDEMIC
PK: M: Liver E: Feces

Indications & Dose: HYPERLIPIDEMIA PO Adult Initially 20mg then adjust at 4 wk intervals, max 80mg/day Child 10-17 yr: IR tablet 10mg/day (for LDL reduction <20%) or 20mg/day (for LDL reduction >20%), adjust at 4 wk intervals, max 40mg/day

Contra: Hypersensitivity, active liver disease, unexplained persistent elevations of serum transaminases

Precautions: Cerebral arteriosclerosis, CVD, renal impairment, severe acute infect, severe hypotension/HTN, uncontrolled seizures, myopathy, visual disturbances, major surgery, trauma, alcoholism, severe metabolic/endocrine/electrolyte problems, patients at risk of rhabdomyolysis, reduce initial dose (by 50%) in patients recieving ciclosporin/danazol

ADR: Serious: blurred vision, Hepatotoxicity, rhabdomyolysis, hypersensitivity reactions, Others: Headache, dizziness, asthenia, eye irritation, nausea, vomiting, constipation, diarrhea, abdominal pain/cramps, dyspepsia, flatulence, myalgia, cramps, pruritus, rash, photosensitivity

DDI: Serious Diltiazem/Ciclosporin/Itraconazole causes marked rise in drug serum levels, Nefazodone causes muscle toxicity & rhabdomyolysis, Danazol causes severe rhabdomyolysis & myoglobinuria, Gemfibrozil/Delavirdine increases drug level, Macrolides increases drug levels (myopathy & rhabdomyolysis)

Diet: With food

Monitor: LFTs, TC profile, baseline CPK

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