Mebendazole

Details About Generic Salt ::  Mebendazole 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Anthelmintics

13L. ANTHELMINTICS in 13. ANTI-INFECTIVES
MEBENDAZOLE
BENZIMIDAZOLE | ANTHELMINTIC
PK: A: Poorly absorbed D: Extensive M: Hepatic E: Feces

Indications & Dose: ALVEOLAR ECHINOCOCCOSIS PO Adult 4.5g/day in 3 divided doses 6 month, may be continued up to 2 yr after radical surgery/ indefinitely in inoperable cases | ASCARIASIS PO Adult 500mg single dose or 100mg BID 3 days Child >1 yr: Same as adult dose | CAPILLARIASIS PO Adult 200mg/day 20-30 days Child >2 yr: Same as adult dose | CYSTIC ECHINOCOCCOSIS PO Adult 4.5g/day in 3 divided doses 6 month | ENTEROBIASIS PO Adult 100mgsingle dose, repeated after interval of 2-3 wk, all household members over 2 yr should be treated at the same time Child >2 yr: Same as adult dose | HOOKWORM INFECT PO Adult 100mg BID 3 days, if eggs persist in feces then start second course after 3-4 wk Child >1 yr: Same as adult dose | TRICHURIASIS PO Adult 100mg BID 3 days, if eggs persist in feces then start second course after 3-4 wk Child >1 yr: Same as adult dose

Precautions: Hepatic impairment

ADR: Serious: raised liver enzymes, bone marrow depression, Others: diarrhea, GI disturbances, headache, dizziness, allergic reactions

DDI: Serious Metronidazole increases the risk of SJS/TEN, Phenobarbital/Carbamazepine/Phenytoin lowers the plasma levels of drug, Cimetidine raises serum drug levels

Diet: with food

Monitor: CBC, LFTs

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