MEFAX 6 250MG | MedicScientist :: Total Health Portal

The Brand Name MEFAX Has Generic Salt :: Mefloquine 

MEFAX  Is From Company Alkem Priced :: Rs. 240

MEFAX have Mefloquine is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Mefloquine  TAB  Rs. 240  6
Brand Name Company / Manufacturers Strength Unit Price / 6
 MEFAX  Alkem  250MG  6 Rs. 240

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Alkem :: MEFAX  Mefloquine  #N/A #N/A

Indications for Drugs ::

Malaria

Drug Dose ::

Adult: PO Malaria As base: 20-25 mg/kg as a single dose or in 2-3 divided doses 6-8 hrly. Max: 1.5 g/dose. Malaria prophylaxis 250 mg/wk taken 1-3 wk before exposure and continuing for 4 wk after leaving the malarious area.

Contraindication ::

Treatment with quinine during the preceding 12 hr. Prophylaxis in patients with history of psychiatric illness, seizure, hepatic disorder. Co-admin with halofantrine due to increased risk of cardiac arrhythmias.

Drug Precautions ::

Epilepsy; delay admin until at least 12 hr after the last dose of quinine/quinine-related compounds (monitoring of cardiac and neurological functions is warranted). Avoid driving or operating machines during and up to 3 wk after mefloquine use. Pregnancy, lactation; cardiac conduction disturbances; children <3 mth or 5 kg. Drug Side Effects ::

Nausea, vomiting, abdominal pain, diarrhoea; dysphoria, dizziness; headache; sleep disorders; vertigo; neuropsychiatric reactions; bradycardia; visual/auditory disturbances; pruritus; sialorrhea, arthralgia and fatigue; syncope; extrasystole. Potentially Fatal: Seizures, thrombocytopenia, leucopenia, AV block, encephalopathy.

Pregnancy category ::
Pregnancy category

3

Drug Mode of Action ::  

Mefloquine is a 4-methanolquinine antimalarial agent and a blood schizontocide which acts by interfering w/ the parasite’s ability to metabolise and utilise erythrocyte Hb. It is active against most Plasmodium sp and is used for prophylaxis and treatment against malaria.

Drug Interactions ::

Increased risk of ECG abnormalities w/ quinine or chloroquine, antihistamines, TCAs and phenothiazines. May increase risk of seizure w/ quinidine or quinine. Concomitant use w/ valproic acid, phenobarbital, carbamazepine and phenytoin may cause loss of seizure control and lower plasma levels of anticonvulsants. Increased risk of QT prolongation and arrhythmia w/ ketoconazole. Concomitant use w/ digoxin, Ca-channel blockers, antiarrhythmics and ?-blockers may increase the risk of cardiotoxicity. Increased risk of ventricular arrhythmias w/ amiodarone. Concomitant use w/ TCAs, SSRIs, buprion, antipsychotic, tramadol may increase the risk of convulsions. Increased plasma levels w/ metoclopromide. May compromise adequate immunisation by live typhoid vaccine. Vaccinations w/ attenuated live bacteria should be completed at least 3 days prior the 1st dose of mefloquine. Potentially Fatal: Avoid concomitant use w/ halofantrine as potentially fatal cardiac arrhythmias may occur.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.