Mefenamic Acid

Details About Generic Salt ::  Mefenamic Acid 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

12E. ANALGESICS & ANTI-INFLAMMATORY DRUGS in 12. MUSCULOSKELETAL DISORDERS & PAIN
MEFENAMIC ACID
ANTHRANILIC ACID DERIVATIVE, NSAID | ANTI-INFLAMMATORY
PK: A: Rapid D: 1.06 L/kg (Vd) M: Hepatic E: Urine (~52%), feces (~20%) as unchanged drug & metabolites

Indications & Dose: PAIN DUE TO PRIMARY DYSMENORRHEA Mild-to-moderate PO Adult Initially 500mg, then 250mg q6h for more than 2-3 days Child >14 yr: Same as adult dose

Contra: Hypersensitivity, perioperative pain in setting of CABG surgery

Precautions: Asthma, patients with fluid retention/HF, history of GI bleeding/PUD, CVD, renal impairment

ADR: Serious: Blood disorders, ARF, interstitial nephritis, hepatitis, blurred vision, tinnitus, hematuria, hepatitis, hepatotoxicity, anaphylaxis, Others: fluid retention, dyspnea, dizziness, nervousness, confusion, depression, malaise, Dysuria, oliguria/polyuria

DDI: Serious Coumarins anticoagulation effects increased, Magnesium Hydroxide increases drug absorption, Lithium toxicity raises

Diet: With food

Monitor: Occult blood loss, CBC, renal function test, LFT

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