The Brand Name MELCYL Has Generic Salt :: Methoxsalen
MELCYL Is From Company EAST WEST Priced :: Rs. 140
MELCYL have Methoxsalen is comes under Sub class Anti Psoriatic Drugs of Main Class Skin
Main Medicine Class:: Skin Sub Medicine Class :: Anti Psoriatic Drugs
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Indications for Drugs ::
Psoriasis, Vitiligo, Eczema, T-Cell Lymphoma
Drug Dose ::
For topical solution dosage form: For vitiligo: Adults and children 12 years of age and over—Apply to the affected area of the skin and allow to dry for one to two minutes, then apply again within two to two and one-half hours before UVA exposure. Methoxsalen lotion is applied only in small well-defined lesions and preferably on lesions that can be protected by clothing or sunscreen from later exposure to UVA. Do not sunbathe for 24 hours before taking methoxsalen and having the UVA light treatment.Take this medication by mouth with food or milk, usually 2 to 4 hours before your UVA light treatment or as directed by your doctor. The dosage of methoxsalen is based on weight, medical condition, and response to treatment. The amount and time of UVA light for each treatment is based on skin type and response to treatment. patient may have UVA light treatments 2 to 4 times a week when first start and then less frequently as condition improves.
Drug Precautions ::
For the treatment of psoriasis, this medication should only be used for severe psoriasis that has not responded well to other treatments since this medication may cause serious side effects (such as cataracts, skin cancer/aging). Patients must not sunbathe during the 24 hours prior to methoxsalen ingestion and UV exposure. The presence of a sunburn may prevent an accurate evaluation of the patient’s response to photochemotherapy.
Drug Side Effects ::
Nausea or trouble sleeping may occur with methoxsalen. Mild itching/drying/reddening/darkening of skin may occur when methoxsalen is used along with UVA light treatment. Unlikely but serious side effects occur: severe reddening of skin, blistering/peeling/burning of skin, thinning/wrinkling skin, painful browning/whitening/yellowing of nails, swelling ankles, mental/mood changes (such as depression, nervousness).
Pregnancy category ::
Drug Mode of Action ::
Methoxsalen increases skin reactivity to long-wavelength UV rays. It bonds covalently to DNA inhibiting DNA synthesis and cell division, which can lead to cell injury. This effect is used in photochemotherapy or PUVA [psoralen (P) and high-intensity long-wavelength UVA irradiation].
Drug Interactions ::
Additive effects with drugs known to cause photosensitisation e.g. anthralin, coal tar or derivatives, griseofulvin, phenothiazines, nalidixic acid, sulfonamides., tetracyclines and thiazide diuretics. May increase the levels/effects of aminophylline, fluvoxamine, mexiletine, mirtazapine, ropinirole, theophylline, trifluoperazine, dexmedetomidine and ifosfamide.