Melphalan

Details About Generic Salt ::  Melphalan 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
MELPHALAN
ALKYLATOR | ANTI-NEOPLASTIC
PK: A: Variable & incomplete (PO) D: 0.5-0.6 L/kg (Vd) M: Hepatic E: Feces (20%-50%), urine (~10% as unchanged drug)

Indications & Dose: MULTIPLE MYELOMA PO Adult Initially 6mg/day for 2-3 wk, then discontinue drug for up to 4 wk or until WBC & platelet counts increase, MD 2mg/day as hematologic recovery begins | IV Adult 16mg/m2 over 15-30min q2wk intervals for 4 doses, then administer at 4wk intervals after adequate hematologic recovery | OVARIAN CARCINOMA PO Adult 0.2mg/kg/day 5 days, repeat q4-5wk

Contra: Hypersensitivity, patients whose disease was resistant to prior melphalan therapy

Precautions: Bone marrow suppression, who received prior/concurrent chemotherapy/irradiation, renal impairment

ADR: Serious: Myelosuppression, blood disorders, secondary malignancy, anaphylaxis, irreversible bone marrow failure, hepatic veno-occlusive disease, suppression of ovarian function in premenopausal women, temporary/permanent sterility in male patients, Others: skin ulceration, necrosis, GI disturbances, diarrhea, vomiting, stomatitis, vasculitis

DDI: Serious Interferon α decreases drug AUC & increases its cytotoxicity, Ciclosporin nephrotoxic effects may increases, Cimetidine reduces drug bioavailability

Diet: On an empty stomach

Monitor: CBC with differential & platelet count, serum electrolytes, serum uric acid

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