Metformin

Details About Generic Salt ::  Metformin 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
METFORMIN
BIGUANIDE | ANTI-DIABETIC
PK: A: Slow D: 654 ± 358(Vd) E: Urine(90%)

Indications & Dose: POLYCYSTIC OVARIAN SYNDROME PO Adult Initially 500mg OD morning 1 wk, then 500mg BID max 1.5–1.7g/day in 2–3 divided doses | TYPE 2 DIABETES MELLITUS PO Adult Initially 500mg OD for at least 1 wk, then 500mg BID 1wk, then 500mg TID, max 2g/day in divided doses, Modified-release preparation: Initially 500mg OD, increase by 500mg, at intervals of at least 1 wk max 2g/day with evening meal Child >10 yr: Initially 500mg OD for at least 1 wk, then 500mg BID 1wk, then 500mg TID, max 2g/day in divided doses

Contra: Hypersensitivity, acute MI, septicemia, acute/chronic metabolic acidosis

Precautions: Elderly, renal/hepatic impairment

ADR: Serious: Hypoglycemia, lactic acidosis, hepatitis, rash, Others: Chills, dizziness, abdominal discomfort, constipation, palpitation, nausea, vomiting, pruritus, headache, dyspepsia

DDI: Serious Gatifloxacin causes abnormal glucose homoeostasis, Fluticasone/Budesonide causes hyperglycemia, Cimetidine causes lactic acidosis, Orlistat increases drug effects, cefalexin increases drug level, Iodinated contrast media may cause renal failure, which could result in lactic acidosis, Disopyramide occasionally causes hypoglycaemia

Diet: With food

Monitor: Urine for glucose & ketones, blood glucose, HbA1c & renal function

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