Miconazole

Details About Generic Salt ::  Miconazole 

Main Medicine Class:: Skin   Sub Medicine Class ::  Anti Microbials (Fungal,

15C. ANTI-MICROBIALS (FUNGAL, PARASITES, VIRAL) in 15. SKIN
MICONAZOLE
IMIDAZOLE DERIVATIVE | ANTI-FUNGAL
also comes under 10H. Vaginal Urethral Preparations in 10. Genito-Urinary System
PK: A: Minimal (PO), negligible (TP) E: Feces, urine (TP)

Indications & Dose: FUNGAL INFECT OF SKIN TP Adult Cream/lotion/powder (2%): Apply twice daily Child Same as adult dose | VAGINAL CANDIDIASIS VAG Adult Intravaginal cream (2%, 5g) inserted into vagina OD 10-14 days or BID 7 days, Pessary: 100mg OD 1-2 wk or 200/400mg OD 3 days or in a single dose of 1200mg

Contra: Hypersensitivity, hepatic impairment

Precautions: For topical use only, avoid contact with eyes, discontinnue if sensitivity/irritation develops

ADR: Serious: Blood disorders, cardiac arrhythmias, arthralgia, transient tachycardia, anaphylaxis, hyponatremia, hyperlipidemia, phlebitis, Others: Nausea, vomiting, diarrhea, anorexia, pruritus, rash, febrile reactions, acute psychosis, drowsiness, local irritation & sensitivity reactions, contact dermatitis, hepatitis

DDI: Serious Coumarins anticoagulant effects increases, Amphotericin-B causes antagonistic effects, Carbamazepine increases adverse effects, Antidiabetics leads to hypoglycemia, Phenytoin/Phenobarbital/Saquinavir levels increases, CCBs levels raises, Terfenadine/Astemizole levels raises & leads to life-threatening arrhythmias, Ciclosporin levels raises by drug (IV), Hormonal Contraceptives levels raises by drug (vaginal), Tobramycin levels reduced

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