Mifepristone

Details About Generic Salt ::  Mifepristone 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Progestins and Anti Progestins

8G. PROGESTINS AND ANTI-PROGESTINS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
MIFEPRISTONE
SYNTHETIC STEROID | ANTI-PROGESTIN, ABORTIFACIENT
also comes under 11C. Oxytocics in 11. Reproductive System
PK: A: Rapid M: Hepatic E: Feces (83%), urine (9%)

Indications & Dose: LABOUR INDUCTION IN FETAL DEATH PO Adult 600mg/day as single dose 2 days under medical supervision | SOFTENING & DILATATION OF CERVIX PO Adult Before surgical termination of pregnancy: 200mg as a single dose 36-48h before procedure during first trimester | TERMINATION OF PREGNANCY PO Adult Day 1: 600mg (three 200mg tablets) as single dose, Day 3: 400µg (two 200µg tablets), Day 14: follow up to confirm complete termination of pregnancy

Contra: Hypersensitivity, chronic adrenal failure, porphyrias, hemorrhagic disorder/concurrent anticoagulant therapy, pregnancy termination >49 days, IUD in place, ectopic pregnancy/undiagnosed adnexal mass, concurrent long-term corticosteroid therapy, inadequate/lack of access to emergency medical services, inability to understand effects/comply with treatment

Precautions: CVD, respiratory/renal/hepatic disorders, HTN, DM, anemia, jaundice, seizure disorder, cervicitis, infected endocervical lesions, acute vaginitis, uterine scarring

ADR: Serious: Uterine hemorrhage, syncope, viral infect, Others: rigors, sinusitis, nausea, vomiting, diarrhea, abdominal cramping, dyspepsia, vaginitis, leukorrhea, uterine cramping, pelvic pain, anemia, fever, Dizziness, fainting, headache, weakness, fatigue, insomnia, asthenia, anxiety

DDI: Serious Corticosteroids efficacy reduces during 3-4 days following intake of drug

Monitor: CBC

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