Milnacipran

Details About Generic Salt ::  Milnacipran 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

1D. ANTI-DEPRESSANTS in 1. NERVOUS SYSTEM
MILNACIPRAN
SNRI | ANTI-DEPRESSANT
PK: A: Well absorbed D: 400L(Vd) M: Hepatic E: Urine

Indications & Dose: DEPRESSION PO Adult Day 1: 12.5mg OD, day 2-3: 12.5mg BID, day 4-7: 25mg BID then 50mg BID thereafter

Contra: Uncontrolled narrow-angle glaucoma, within 2 wk of MAOI use

Precautions: Abrupt discontinuation, hepatic impairment, controlled narrow-angle glaucoma

ADR: Serious: scrotal pain/testicular swelling, urinary retention, ARF, SJS, blurred vision, Others: rash, headache, insomnia, hot flashes, HTN, dizziness, vomiting

DDI: Serious Clonidine action reduces, Noradrenaline/Adrenaline/Selegiline increases risk of hypertensive crisis in patients with cardiac arrhythmia, MAOIs/Lithium increases risk of serotonin syndrome

Diet: With food

Monitor: BP, HR, renal function test, IOP

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