Minocycline

Details About Generic Salt ::  Minocycline 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Tetracyclines

15K. DRUGS FOR ACNE in 15. SKIN
MINOCYCLINE
ANTIBIOTIC, TETRACYCLINE DERIVATIVE | ANTI-INFECTIVE
also comes under 13F. Tetracyclines in 13. Anti-Infectives,  
PK: A: Well absorbed M: Hepatic E: Urine, feces

Indications & Dose: ACNE PO Adult 50-100mg BID Child 12–18 yr: 100mg/day | CHLAMYDIAL INFECT Uncomplicated PO/IV Adult 100mg BID 1 wkUrethral, endocervical/rectal | GONOCOCCAL INFECTION Uncomplicated PO/IV Adult Without urethritis/anorectal infect: Initially 200mg followed by 100 mg BID 4 days; Urethritis: 100mg BID 5 days | MYCOBACTERIUM MARINUM PO Adult 100mg BID 6-8 wk | SYPHILIS PO/IV Adult Initially 200mg, followed by 100mg BID 10-15 days

Contra: Hypersensitivity, children <8 yrs, SLE

Precautions: Sulfite sensitivity, renal disease, hepatic impairment, nephrogenic DI, cachectic/debilitated patients, avoid direct exposure to sunlight/artificial UV light, myasthenia gravis

ADR: Serious: Pericarditis, hemolytic anemia, thrombocytopenia, anaphylaxis, superinfection, hypersensitivity reactions, Others: headache, pharyngitis, nausea, vomiting, diarrhea, oral candidiasis, stomatitis, mouth ulcers, bladder/vaginal yeast infect, eosinophilia, photosensitivity, rash, dental caries/infect, gingivitis, tooth disorder/pain/discoloration

DDI: Serious Hormonal Contraceptives causes contraceptive failure by drug (long term), Ethinylestradiol leads to pigmentation, Retinoids leads to pseudotumor cerebri (benign intracranial HTN), Ritonavir/Atazanavir level reduces, Iron compounds markedly reduces absorption of both the drugs, Lithium renal clearance adversely get affected by drug

Diet: With/without food

Monitor: LFTs, BUN, renal function test with long-term treatment, symptomatic for autoimmune disorder (include ANA, CBC)

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