Moclobemide

Details About Generic Salt ::  Moclobemide 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Depressants

1D. ANTI-DEPRESSANTS in 1. NERVOUS SYSTEM
MOCLOBEMIDE
RIMA | ANTI-DEPRESSANT, ANXIOLYTIC
also comes under 1B. Anxiolytics in 1. Nervous System
PK: A: Rapid D: 1.2L/kg(Vd) M: Hepatic E: Urine

Indications & Dose: DEPRESSION PO Adult Initially 300mg/day in 2 divided doses, increase gradually to max 600mg/day | SOCIAL ANXIETY DISORDER PO Adult Initially 300mg increased after 3 days to 600mg, given in 2 divided doses for 8-12 wk

Contra: Hypersensitivity, confusional states, concurrent use of sympathomimetics/MAOI/meperidine/TCA/thioridazine/serotonergic drugs (including SSRIs), excited/agitated patients

Precautions: Renal impairment, pheochromocytoma, thyroid dysfunction, thyrotoxicosis, severe hepatic impairment

ADR: Serious: Tachycardia, hypotension, tremor, angina, bradycardia, conjunctivitis, HTN, flushing, EPS, tinnitus, visual disturbances, Others: extrasystoles, gastritis, gingivitis, hallucinations, heartburn, insomnia, malaise, migraine, paresthesia, phlebitic symptoms, photopsia, polyuria, prolonged menstruation, pruritus, rash, skeletal pain, stomatitis, taste alteration, delusions, disorientation, dry skin, dysarthria, dyspnea, dysuria, excitation, cold sensation, confusion, apathy, blurred vision, aggression, allergic reaction, sleep disturbance, agitation, nervousness, anxiety, constipation, diarrhea, vomiting

DDI: Serious Sumatriptan bioavailability increases, SSRIs causes serotonin syndrome, Metoprolol hypotensive effect increases, Cimetidine increases drug plasma levels, Dextromethorphan metabolism is inhibited, Rizatriptan metabolism is markedly inhibited, Zolmitriptan metabolism is modestly inhibited

Diet: Immediately after food

Monitor: BP, suicidal ideation

Related Posts:
You May Also Like::
Tagged with