Nalidixic acid

Details About Generic Salt ::  Nalidixic acid 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13G. QUINOLONES in 13. ANTI-INFECTIVES
NALIDIXIC ACID
FLUOROQUINOLONE | ANTI-INFECTIVE
PK: A: Rapid & complete M: Hepatic E: Urine

Indications & Dose: SHIGELLOSIS Acute PO Adult 4g/day 4 divided doses 2wk | Chronic PO Adult 2g/day 4 divided doses 2wk | URINARY TRACT INFECT PO Adult 1g QID 2wk, then suppressive therapy of 500mg QID Child 3 month-12yr: 55mg/kg/day in 4 divided doses, suppressive therapy of 30mg/kg/day in 4 divided doses

Contra: History of convulsive disorders, severe renal impairment, infants

Precautions: hepatic impairment, severe cerebral arteriosclerosis, G6PD deficiency, moderate renal impairment

ADR: Serious: arthralgia, tendon damage, toxic psychoses, convulsions, intracranial HTN, SJS, angioedema, Others: metabolic acidosis, nausea, vomiting, diarrhea, abdominal pain, urticaria, pruritus, erythema multiforme, fever, eosinophilia, dizziness, drowsiness, depression, hallucination

DDI: Serious Acenocoumarol causes hypoprothrombinemia, Nitrofurantoin effect antagonizes, Coumarins increases bleeding time, Probenecid increases drug level

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