Naratriptan

Details About Generic Salt ::  Naratriptan 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Migraine , Anti Vertigo Drugs

1H. ANTI-MIGRAINE & ANTI- VERTIGO DRUGS in 1. NERVOUS SYSTEM
NARATRIPTAN
SELECTIVE SEROTONIN 5-HT1 AGONIST | ANTI-MIGRAINE
PK: A: Well absorbed D: Vdss: 170 L M: Hepatic E: Urine (50% as unchanged drug, 30% as metabolites

Indications & Dose: MIGRAINE Acute PO Adult 2.5mg, if symptoms recur, second dose after 4h interval, max 5mg/dayDiscontinue if ineffective after first dose

Contra: Hypersensitivity, hemiplegic/basilar headaches, severe renal/cardiovascular/hepatic impairment, history of cerebrovascular/ peripheral vascular conditions, ischemic bowel disease, uncontrolled hypertension, use of ergot-type drugs (such as dihydroergotamine) and other 5-HT1 agonists within 24 hours, MAOIs use within past 14 days

Precautions: mild to moderate renal/hepatic impairment, cardiovascular risk factors, elderly, children

ADR: Serious: coronary artery vasospasm, MI, ventricular fibrillation/tachycardia

DDI: Others Sibutramine increases naratriptan levels, Serotonin modulators/Ergot derivatives levels increases

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