The Brand Name NELOP Has Generic Salt :: Loperamide
NELOP Is From Company Nestor Priced :: Rs. 12.7
NELOP have Loperamide is comes under Sub class #N/A of Main Class #N/A
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
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Indications for Drugs ::
Drug Dose ::
Adult: Acute Diarrhea 4 mg initially, then 2 mg after each loose stool; not to exceed 16 mg/day (8 mg/day for self-medication); discontinue if no improvement seen within 48 hours. Chronic Diarrhea 4 mg initially, then 2 mg after each loose stool until controlled, and then 4-8 mg/day in divided doses Traveler’s Diarrhea. 4 mg after first loose stool, then 2 mg after each subsequent stool; not to exceed 8 mg/day Children: Acute Diarrhea First Day of Treatment 2-6 years (13-20 kg): 1 mg q8hr PO 6-8 years: (20-30 kg): 2 mg q12hr PO 8-12 years (>30 kg): 2 mg q8hr PO Second & Subsequent Doses 0.1 mg/kg PO after each loose stool; not to exceed dose recommended for first 24 hours Chronic Diarrhea 0.08-0.24 mg/kg/day PO divided q12hr Traveler’s Diarrhea <6 years: safety and efficacy not established 6-8 2 mg after first loose stool, then 1 each subsequent stool; to exceed 4>12 years: 4 mg after first loose stool, then 2 mg after each subsequent stool; not to exceed 8 mg/day
Conditions when inhibition of peristalsis is undesirable (e.g. ileus or megacolon); antibiotic induced colitis; active inflammatory bowel disease; if abdominal distention develops during use; abdominal pain in the absence of diarrhoea.
Drug Precautions ::
Concomitant specific therapy must be given in those with infectious diarrhoea; hepatic dysfunction; infants; pregnancy, lactation.
Drug Side Effects ::
Abdominal pain, distention, and discomfort; paralytic ileus; constipation, dry mouth, drowsiness, dizziness, fatigue, rash. Potentially Fatal: Toxic megacolon.
Pregnancy category ::
Drug Mode of Action ::
Loperamide inhibits peristalsis and prolongs transit time by acting directly on intestinal wall muscles. It also reduces faecal volume, increases viscosity and decreases fluid and electrolyte loss.. Slows intestinal motility through opioid receptor; has direct effects on circular and longitudinal muscle;.
Drug Interactions ::
Bioavailability increased by co-trimoxazole, ritonavir, saquinavir. Respiratory depression reported when administered with quinidine. Loperamide increases GI absorption of desmopressin and decreases exposure to saquinavir.