Noradrenaline

Details About Generic Salt ::  Noradrenaline 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

4A. DRUGS FOR CARDIAC FAILURE & SHOCK in 4. CARDIOVASCULAR SYSTEM
NORADRENALINE
SYMPATHOMIMETIC | A- & ß-ADRENERGIC AGONIST, CARDIAC STIMULANT, VASOPRESSOR
PK: M: Hepatic E: Urine

Indications & Dose: CARDIOPULMONARY RESUSCITATION IV Adult Inf: Initially 8-12µg/min, titrate to desired response, MD 2-4µg/min Child 0.1-2µg/kg/min | HYPOTENSION IV Adult Inf: Initially 8-12µg/min (2-3mL/min) titrated to desired response, MD 2-4µg/min (0.5-1mL/min) Child Inf: Neonate, 1 month–18 yr: 20–100ng(base)/kg/min adjusted according to response max 1µg (base)/kg/min | SHOCK IV Adult Inf: Initially 8-12µg/min, titrate to desired response, MD 2-4µg/min Child Initially 0.05-0.1 µg/kg/min, titrate to desired effect, max 2µg/kg/min | UPPER GI HEMORRHAGE IP Adult 8mg (250 mL of 0.9% Nacl)

Contra: Hypersensitivity, hypotension due to hypovolemia, mesenteric/peripheral vascular thrombosis, during anesthesia with cyclopropane/halothane anesthesia, profound hypoxia/hypercapnia

Precautions: Concurrent use of MAOI/TCA, sulfite sensitivity, children

ADR: Serious: Severe HTN, arrhythmias, bradycardia, respiratory difficulty, skin necrosis, Others: headache, anxiety

DDI: Serious Guanethidine causes HTN, Hydralazine causes tachycardia, MAOIs increases pressor effects of drug, TCAs leads to exaggerated response (HTN, cardiac arrhythmias)

Monitor: BP & cardiac, CNS status, skin temperature,fluid status, assess inf site frequently for extravasation

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