Ofloxacin

Details About Generic Salt ::  Ofloxacin 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Quinolones

3C. ANTI-INFECTIVES in 3. OCULAR
OFLOXACIN
FLUOROQUINOLONE | ANTI-INFECTIVE
also comes under 13G. Quinolones in 13. Anti-Infectives,  2A. Anti-Infectives in 2. Ear, Nose & Throat (ENT)
PK: A: Well absorbed D: 2.4-3.5 L/kg (Vd) M: Hepatic E: Urine (Unchanged drug)

Indications & Dose: ACUTE EXACERBATION CHRONIC BRONCHITIS PO Adult 400mg BID 10 days | BRUCELLOSIS PO Adult 400mg OD along with rifampicin (600mg/day) 6 wk | CHRONIC SUPPURATIVE WITH PERFORATED TYMPANIC MEMBRANES TP Adult Solution (0.3%): Instill 10 drops into affected ear BID 2 wk Child >12 yr: Same as adult dose | COMMUNITY-ACQUIRED PNEUMONIA PO Adult 400mg BID 10 days | CONJUNCTIVITIS TP Adult Solution (0.5%): Instill 1-2 drops in affected eye q2-4h for first 2 days, then QID for next 5 days Child > 1 yr: Same as adult dose | CORNEAL ULCER TP Adult Solution (0.5%): Instill 1-2 drops q30min while awake & q4-6h after retiring for the first 2 days, beginning on day 3, instill 1-2 drops q1h while awake for next 4-6 days, then 1-2 drops QID until clinical cure Child > 1 yr: Same as adult dose | GONOCOCCAL CERVICITIS/URETHRITIS Acute/Uncomplicated PO Adult 400mg single dose | LEGIONNAIRES’ DISEASE PO Adult 400mg BID 2-3 wk | MULTIBACILLARY LEPROSY PO Adult 400mg once monthly 2 yras a part of multiple drug regimen | NON-GONOCOCCAL CERVICITIS/URETHRITIS PO Adult 300mg BID 7days | OTITIS EXTERNA TP Adult Solution (0.3%): Instill 10 drops into affected ear OD 1 wk Child Solution (0.3%): 6 months-13 yr: Instill 5 drops into affected ear OD 7 days, >13 yr: Same as adult dose | OTITIS MEDIA TP Adult Solution (0.3%): Instill 10 drops into affected ear BID 2 wk Child >12 yr: Same as adult dose | OTITIS MEDIA WITH TYMPANOSTOMY TUBES Acute TP Child Solution (0.3%): 1-12 yr: Instill 5 drops into affected ear BID 10 days | PELVIC INFLAMMATORY DISEASE Acute PO Adult 400mg BID 10-14 days with/without metronidazole | PROSTATITIS Acute PO Adult 400mg for 1 dose, then 300mg BID 10 days | Chronic PO Adult 200mg BID 6 wk | SINGLE LESION PAUCIBACILLARY LEPROSY PO Adult 400mg single dose Child 5-14 yr: 200mg single dose | SKIN/SKIN STRUCTURE INFECT Uncomplicated PO Adult 400mg BID 10 days | TYPHOID FEVER PO Adult 200-400mg BID 1-2 wks | URINARY TRACT INFECT Uncomplicated PO Adult 200mg BID 3-7 days | Complicated PO Adult 200mg BID 10 days

Contra: Hypersensitivity, exposure to strong sunlight/sunlamps

Precautions: CNS disease, renal impairment, cirrhosis, bradycardia, acute myocardial ischemia, history of tendinitis/tendon rupture with fluoroquinolone use, dialysis patients, elderly, children, epilepsy/history of CNS disorders, G6PD deficiency, myasthenia gravis, with QT prolongation, uncorrected electrolyte disturbances, pre-existing CVD

ADR: Serious: Chest pain, pseudomembranous colitis, pancreatitis, visual disturbances, tremor, convulsions, intracranial HTN, psychotic reactions, peripheral neuropathy, hypersensitivity-type reactions, erythema multiforme, SJS, TEN, Tendon damage, crystalluria, hepatitis, blood disorder, hypotension, Others: photophobia, reversible arthralgia/myalgia, rash, depression, drowsiness, nightmares, pharyngitis, headache, dysphagia, restlessness, insomnia, dizziness, fatigue, somnolence, sleep disorders, nervousness, pyrexia, rash/pruritus, diarrhea, vomiting, GI distress, abdominal cramps, xerostomia, appetite decreased, nausea, constipation, vaginitis

DDI: Serious Procainamide increases serum levels moderately by drug, Sucralfate markedly reduces absorption of drug, Iron compounds reduces absorption from gut

Monitor: Signs & symptoms of superinfection, hypersensitivity reaction, neurologic status

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