Omeprazole

Details About Generic Salt ::  Omeprazole 

Main Medicine Class:: Gastrointestinal System   Sub Medicine Class ::  GERD,

7A. GERD, ULCER/ANTACIDS in 7. GASTROINTESTINAL SYSTEM
OMEPRAZOLE
PPI | ANTI-ULCER
PK: A: Well absorbed M: Hepatic E: Urine (~77% as metabolites) & feces

Indications & Dose: ACID ASPIRATION DURING GENERAL ANAESTHESIA PO Adult 40mg administer evening before surgery & further 40mg 2-6h before procedure | ACID-RELATED DYSPEPSIA PO Adult 10 or 20mg/day 2-4 wk | ACTIVE DUODENAL ULCER PO Adult 20mg OD 4-8 wk Child 10-20 kg: 10mg OD, >20 kg: 20mg OD 4-12 wk, doses may be doubled if needed | EROSIVE ESOPHAGITIS PO Adult 20mg OD for 4-8 wk, MD 20mg OD up to 12 months | GASTRIC ULCERS PO Adult 40mg OD 4-8 wk Child 10-20 kg: 10mg OD; >20 kg: 20mg OD 4-12 wk, doses may be doubled if needed | GASTROESOPHAGEAL REFLUX DISEASE PO Adult 20mg OD 4 wk Child 10-20 kg: 10mg OD, >20 kg: 20mg OD 4-12 wk, doses may be doubled if needed | IV Child Inj: 12–18 yr: 40mg OD over 5min | H.PYLORI ERADICATION Combination therapy PO Adult Triple therapy: Omeprazole 20mg BID or 40mg OD with amoxicillin 500mg & metronidazole 400mg both TID or clarithromycin 250mg & metronidazole 400mg both BID for 1 wk, Dual therapy: Omeprazole 20mg BID or 40mg/day with either amoxicillin 750mg-1g BID or clarithromycin 500mg TID for 2 wk. Omeprazole alone may be continued for next 4-8 wk | NSAID-INDUCED GASTRIC ULCERS PO Adult 20mg/day Child 10-20 kg: 10mg OD, >20 kg: 20mg OD 4-12 wk, doses may be doubled if needed | ZOLLINGER-ELLISON SYNDROME PO Adult 60mg OD

Contra: Hypersensitivity

Precautions: Hepatic disease, children, rule out malignancy

ADR: Serious: hepatitis, blood disorders, interstitial nephritis, increase the risk of GI infect, hypersensitivity reactions, Others: hallucinations, dizziness, headache, asthenia, nausea, vomiting, diarrhea, constipation, abdominal pain, back pain, cough, URTI, rash, arthralgia, myalgia, dry mouth

DDI: Serious Bismuth absorption & bioavailability increases by drug, Clopidogrel antiplatelet action reduces by drug, Clarithromycin doubles the serum levels of drug, Methotrexate excretion reduces by drug, Indinavir/Clozapine level reduces by drug, Furazolidone level reduces modestly by drug, Escitalopram levels increases by drug, Sibutramine/Saquinavir levels increases moderately by drug, Ticlopidine markedly decreases the clearance & increases the bioavailability of drug, Voriconazole/Fluconazole markedly increases drug level, Fluvoxamine markedly inhibits the metabolism of drug, Hormonal Contraceptives modestly inhibit the metabolism of drug, Ketoconazole reduces bioavailability & increases drug levels, Itraconazole reduces bioavailability by drug

Diet: Before food

Monitor: Assess vital signs, check for abdominal pain, emesis,diarrhea/constipation, evaluate fluid intake & output

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