Details About Generic Salt ::  Paclitaxel 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
PACLITAXEL
ANTI-NEOPLASTIC
PK: D: Extensive M: Hepatic E: Feces (~70%, 5% as unchanged drug), urine (14%)

Indications & Dose: ADVANCED OVARIAN EPITHELIAL CANCER Mono therapy/Second-line therapy IV Adult 135/175mg/m2 over 3h q3wk in patients with metastatic carcinoma who failed to respond to first-line therapy | First-line therapy IV Adult 175mg/m2 over 3h q3wk or 135mg/m2 over 24h q3wk, followed by cisplatin (IV, 75mg/m2) | AIDS-RELATED KAPOSI’S SARCOMA IV Adult 135mg/m2 over 3h q3wk or 100mg/m2 over 3h q2wk | METASTATIC BREAST CANCER Second-line therapy IV Adult Refractory to initial chemotherapy/breast cancer that has relapsed after 6 months of adjuvant therapy:175mg/m2 over 3h q3wk | NODE-POSITIVE BREAST CANCER First-line therapy IV Adult 175mg/m2 as inf over 3h q3wk for 4 courses given sequentially with doxorubicin combination chemotherapy | NON-SMALL-CELL LUNG CANCER Combination therapy IV Adult 135mg/m2 over 24h q3wk, followed by cisplatin (IV, 75mg/m2), may be repeated q3wk

Contra: Hypersensitivity, absolute neutrophil count <1500 cells/mm3, acute infect

Precautions: Hepatic dysfunction, elderly, children, debilitated patients, depressed bone marrow from radiotherapy/therapy with other anti-neoplastics

ADR: Serious: Flushing, ECG abnormal, edema, hypotension, peripheral neuropathy, arthralgia/myalgia, creatinine increased, hypersensitivity reaction, infect, bradycardia, tachycardia, HTN, syncope, venous thrombosis, blood disorders, bleeding, AST/alkaline phosphatase increased, febrile neutropenia, bilirubin increased, Others: dyspnea, Inj site reaction, nail changes, alopecia, rash, nausea, vomiting, diarrhea, mucositis, stomatitis, abdominal pain

DDI: Serious Verapamil (high-dose) reduces drug clearance & increases the incidence of hematological toxicity, Epirubicin/Doxorubicin causes cardiotoxicity, Carboplatin causes neurotoxicity, Cisplatin causes severe myelosuppression if cisplatin is given first, Warfarin effects increases (bleeding), Phenobarbital/Carbamazepine/Phenytoin increases drug clearance & increase its maximum tolerated dose, Gemfibrozil/Ciclosporin increases drug level, HIV protease inhibitors leads to life-threatening hematological toxicities, Cyclophosphamide leads to toxicity

Monitor: CBC with differential, monitor for hypersensitivity reactions, vital signs (frequently during first hour of Inf), continuous cardiac monitoring (patients with conduction abnormalities)

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.