PHYTORAL 10 200MG

The Brand Name PHYTORAL Has Generic Salt :: Ketoconazole 

PHYTORAL  Is From Company Brown & B. Priced :: Rs. 150

PHYTORAL have Ketoconazole is comes under Sub class Anti Microbials (Fungal, of  Main Class Skin

Main Medicine Class:: Skin  Sub Medicine Class :: Anti Microbials (Fungal

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Ketoconazole  TAB  Rs. 150  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 PHYTORAL  Brown & B.  200MG  10 Rs. 150

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Brown & B. :: PHYTORAL  Ketoconazole  Skin Anti Microbials (Fungal,

Indications for Drugs ::

Dandruff, Seborrheic dermatitis of the scalp, Pityriasis versicolor

Drug Dose ::

To use the Ketoconazole shampoo, follow these steps: Use a small amount of water to wet the area where Ketoconazole shampoo is to be applied. Apply the shampoo to the affected skin/scalp and a large area around it. Use fingers to rub the shampoo until it forms lather. Leave the shampoo on skin/scalp for 5 minutes. Rinse the shampoo off skin/scalp with water. Treatment: Pityriasis versicolor: once daily for 5 days. Seborrhoeic dermatitis and Pityriasis capitis: twice weekly for 2 to 4 weeks. Prophylaxis: Pityriasis versicolor: once daily for 3 days during a single treatment course before the summer. Seborrhoeic dermatitis and Pityriasis capitis: once every 1 or 2 weeks.

Contraindication ::

Known hypersensitivity to ketoconazole or any of the excipients.

Drug Precautions ::

In patients who have been on prolonged treatment with topical corticosteroids, it is recommended that the steroid therapy be gradually withdrawn over a period of 2 to 3 weeks, while using Ketoconazole 2% shampoo to prevent any potential rebound effect. Avoid contact with the eyes. If the shampoo enters the eyes, rinse immediately with plenty of water.

Drug Side Effects ::

Topical treatment with Ketoconazole 2% shampoo is generally well tolerated. As with other shampoos, a local burning sensation, itching, or contact dermatitis (due to irritation or allergy), may occur on exposed areas. In rare instances, mainly in patients with chemically damaged hair or gray hair, a discoloration of the hair has been observed with the use of Ketoconazole 2% shampoo.

Pregnancy category ::
Pregnancy category

3

Drug Mode of Action ::  

Ketoconazole interferes w/ biosynthesis of triglycerides and phopholipids by blocking fungal CYP450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.

Drug Interactions ::

Reduced absorption w/ antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Reduced plasma concentrations w/ rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. May also reduce concentrations of isoniazid and rifampicin. May reduce efficacy of oral contraceptives. May increase serum levels of CYP3A4 substrates e.g. digoxin, oral anticoagulants, sildenafil, tacrolimus. Potentially Fatal: May potentiate and prolong sedative and hypnotic effects of midazolam and triazolam. Increased plasma levels and prolonged QT intervals of astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine which may lead to torsade de pointes. Increased risk of myopathy w/ HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin). Markedly increased plasma levels of nisoldipine. Increased risk of hyperkalaemia and hypotension w/ eplerenone. Increased risk of vasospasm potentially leading to cerebral ischaemia w/ ergot alkaloids (e.g. ergotamine, dihydroergotamine).

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.
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