Pioglitazone

Details About Generic Salt ::  Pioglitazone 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
PIOGLITAZONE
THIAZOLIDINEDIONE | ANTI-DIABETIC
PK: A: Rapid M: Hepatic E: Urine (15%-30%)& feces

Indications & Dose: TYPE 2 DIABETES MELLITUS Combination therapy PO Adult Initially 15-30mg/day with metformin max 45mg/day | Combination therapy PO Adult Initially 15-30mg/day with insulin, dose of insulin should be reduced by 10%-25% if hypoglycemia occurs/if the plasma glucose falls to <100 mg/dL | Combination therapy PO Adult Initially 15-30mg/day with sulfonylurea max 45mg/day. Dose of sulfonylurea should be reduced if hypoglycemia occurs | Mono therapy PO Adult Initially 15-30mg/day, increase by 45mg/day if inadequate response max 45mg/day

Contra: Hypersensitivity, hepatic impairment, history of heart failure

Precautions: CVD, combination with insulin, substitute insulin during peri-operative period

ADR: Serious: HF, hypoglycemia, altered blood lipids, hepatic toxicity, hematuria, Others: GI disturbances, weight gain, edema, headache, dizziness, arthralgia, hypoesthesia, fatigue, insomnia, vertigo, proteinuria

DDI: Serious Gatifloxacin causes hypoglycemia, Insulin Regular causes peripheral edema, NSAIDs leads to fluid retention

Diet: With/without food

Monitor: Glucose, HbA1c, signs/symptoms of HF & LFTs

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