The Brand Name POSID Has Generic Salt :: Etoposide
POSID Is From Company Cadila Priced :: Rs. 210
POSID have Etoposide is comes under Sub class Anti Neoplastic Agents of Main Class Anti Neoplastic Agents
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
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Indications for Drugs ::
Lung cancer, Testicular cancer
Drug Dose ::
Adult: IV Testicular cancer Combination therapy: 50-100 mg/m2/day from days 1-5. May repeat course 3-4 wkly. Small cell lung cancer 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days. May repeat course 3-4 wkly. Renal impairment: CrCl (ml/min) 15-50 75% of the recommended dose.
Hypersensitivity, pregnancy, lactation.
Drug Precautions ::
Skin reactions may occur with accidental exposure; renal or hepatic disease. Periodic CBCs should be done before, during and after therapy. Increased risk of etoposide-toxicity in patients with low serum albumin. Acrylic material has been shown to crack and leak when used with undiluted etoposide inj.
Drug Side Effects ::
Nausea, vomiting, anorexia, diarrhoea, stomatitis; reversible alopoecia; rarely, disturbances of liver dysfunction, peripheral neuropathy, CNS effects, anaphylactoid reactions; hypotension with IV injection. Local irritation and thrombophloebitis at the site of inj. Potentially Fatal: Severe myelosuppression, characterised by leucopaenia and thrombocytopaenia. Cardiotoxicity. Anaphylaxis.
Pregnancy category ::
Drug Mode of Action ::
Etoposide is a derivative of podophyllotoxin that inhibits DNA synthesis resulting in the arrest of the cell cycle. At low doses, it inhibits cells from entering cell cycle and at high doses, cells entering mitosis are lysed.
Drug Interactions ::
Synergism with other cytotoxic drugs. Caution when admin with drugs that inhibit phosphatase activity. Cyclosporin A may reduce the clearance of etoposide.