Pramipexole

Details About Generic Salt ::  Pramipexole 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Drugs for Neurodegenerative Disorders

1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM
PRAMIPEXOLE
NON-ERGOT DOPAMINE AGONIST | ANTI–PARKINSONIAN
PK: A: Rapid D: 500L(Vd) M: Minimal E: Urine

Indications & Dose: PARKINSON’S DISEASE PO Adult Initially 0.375mg/day in 3 divided doses, may be increases q5-7 days gradually, max 1.5-4.5mg/day | RESTLESS LEGS SYNDROME PO Adult Initially 125µg/day as single dose 2-3h before bedtime, may be increased to 250µg/day after 4-7 days, followed by 250µg/day q4-7days max 750µg/day

Contra: hypersensitivity

Precautions: renal impairment, pre-existing dyskinesias, risk of HTN, CNS depressants, impulse control disorders, retroperitoneal fibrosis, elderly

ADR: Serious: postural hypotension, arthritis, myasthenia, rhinitis, pneumonia, tremor, libido decreased, retroperitoneal fibrosis, pulmonary infiltrates, pleural thickening, muscle twitching, vision abnormalities, Others: confusion, dystonia, hypesthesia, akathisia, malaise, delusions, amnesia, myoclonus, anorexia, back pain, dyspepsia, dysphagia, salivary hypersecretion, urinary frequency, gait abnormalities

DDI: Serious Cimetidine/Amantadine/Probenecid reduces drug clearance

Diet: With/without food

Monitor: Vital signs, body weight, CNS depression

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