Pregabalin

Details About Generic Salt ::  Pregabalin 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Epileptics

1J. DRUGS FOR NEUROPATHIC PAIN in 1. NERVOUS SYSTEM
PREGABALIN
GABA DERIVATIVE | ANTI-EPILEPTIC, ANXIOLYTIC
also comes under 1C. Anti-Epileptics in 1. Nervous System,  1B. Anxiolytics in 1. Nervous System
PK: A: Rapid D: 0.5L/kg (Vd) E: Urine (90%)

Indications & Dose: ANXIETY PO Adult Initially 150mg/day in 2–3 divided doses, increase if necessary at 7-day intervals in steps of 150mg/day, max 600mg/day in 2–3 divided doses | FIBROMYALGIA PO Adult Initially 150mg/day, increase to 300mg/day after 1 wk according to response, followed by 450mg/day | PARTIAL SEIZURES WITH/ WITHOUT SECONDARY GENERALIZATION Adjunct therapy PO Adult Initially 25mg BID, increase at 7-day intervals in steps of 50mg-300mg/day in 2–3 divided doses, increase further after 7 days to max 600mg/day in 2–3 divided doses | PERIPHERAL & CENTRAL NEUROPATHIC PAIN PO Adult Initially 150mg/day in 2–3 divided doses, increase if needed after 3–7 days to 300mg/day in 2–3 divided doses, increase further after 7 days to max 600mg/day in 2–3 divided doses

Contra: Hypersensitivity

Precautions: Avoid abrupt withdrawal, CRF, CHF

ADR: Serious: First-degree AV block, arrhythmia, dysuria, thrombocytopenia, joint swelling, pancreatitis, hypotension, hypoglycaemia, rhabdomyolysis, hypokalemia, CHF, angioedema, SJS, arthralgia, Others: pruritus, hyperglycemia, nausea, vomiting, constipation, drowsiness, flatulence, paresthesia, confusion, fatigue, diplopia, insomnia, myalgia

DDI: Serious Lorazepam/Alcohol efficacy is increased, Oxcarbazepine/Carbamazepine/Phenytoin may reduce drug level

Diet: With/without food

Monitor: Symptoms of myopathy, skin integrity, weight gain, suicidality

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