The Brand Name PRIMODIL Has Generic Salt :: Amlodipine
PRIMODIL Is From Company Medley Priced :: Rs. 14.7
PRIMODIL have Amlodipine is comes under Sub class Anti Anginals of Main Class Cardiovascular System
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Anti Anginals
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Indications for Drugs ::
Mild to moderate hypertension, Chronic stable and vasospastic angina, Raynaud’s disease, Coronary Artery Disease, HTN, Stroke prevention
Drug Dose ::
Adult: PO Stable angina; HTN; Prinzmetal’s angina Initial: 5 mg once daily; If the desired therapeutic effect cannot be achieved within 2-4 weeks, the dose may be increased to a maximum dose of 10 mg once daily. Child: >12 yr Initially, 2.5 mg once daily, increased to 5 mg once daily if necessary. Elderly: Initially, 2.5 mg once daily. Hepatic impairment: Initially, 2.5 mg once daily.
Hypersensitivity to Amlodipine or other calcium channel antagonist, Severe hypertension.
Drug Precautions ::
Impaired liver or renal function, CHF, sick-sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, severe aortic stenosis. Caution when used in patients with idiopathic hypertrophic subaortic stenosis. Elderly, children. Pregnancy, lactation. Use in renal failure: Although Amlodipine is excreted primarily via kidney, mild renal impairment does not appear to have an effect on the plasma concentrations. Severe renal impairment may however require a dosage reduction. Amlodipine is not dialyzable. Use in patients with impaired hepatic function: Amlodipine half-life is prolonged in patient with impaired hepatic function. Amlodipine should therefore be administered at lower (5mg) initial dose in these patients. Use in heart failure: An increased number of pulmonary oedema has been reported.
Drug Side Effects ::
Headache, peripheral oedema, fatigue, somnolence, nausea, abdominal pain, flushing, dyspepsia, palpitations, dizziness. Rarely pruritus, rash, dyspnoea, asthenia, muscle cramps.Potentially Fatal: Hypotension, bradycardia, conductive system delay and CCF.
Pregnancy category ::
Drug Mode of Action ::
Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.
Drug Interactions ::
Plasma concentrations may be elevated w/ CYP3A4 inhibitors (e.g. azole antifungals, ritonavir). Concomitant therapy w/ simvastatin may increase risk of myopathy including rhabdomyolysis. May increase ciclosporin plasma levels and conivaptan.