Promethazine

Details About Generic Salt ::  Promethazine 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Sedatives , Hypnotics

6B. ANTI-HISTAMINES AND NASAL DECONGESTANTS in 6. RESPIRATORY SYSTEM
PROMETHAZINE
SEDATING ANTI-HISTAMINE | ANTI-ALLERGIC, ANTI-EMETIC, SEDATIVE & HYPNOTIC
also comes under 1A. Sedatives & Hypnotics in 1. Nervous System,   7D. Anti-Emetics in 7. Gastrointestinal System
PK: A: Well absorbed D: Extensive M: Hepatic E: Urine & bile

Indications & Dose: ALLERGIC CONDITIONS/URTICARIA PO Adult 25mg HS or 12.5mg before meals & HS Child >2 yr: 0.1mg/kg/dose, max 12.5mg q6h during day & 0.5mg/kg/dose max 25mg HS if needed | ANTIEMETIC PO/IV/IM/RECTAL Adult 12.5-25mg q4-6h Child 0.25-1mg/kg 4-6 times/day max 25mg/dose | HYPNOTIC ADJUNCT Combination therapy IV/IM Adult 25-50mg with an analgesic or hypnotic Child >2 yr: 1.1mg/kgwith an analgesic or hypnotic at low dose | MOTION SICKNESS Prophylactic therapy PO/RECTAL Adult 25mg 30-60min before departure then q12h if needed Child 0.5mg/kg/dose 30-60min before departure then q12h if needed, max 25mg BID | PRE/POSTOPERATIVE ANALGESIA Combination therapy IV/IM Adult 25-50mg with an analgesic or hypnotic Child >2 yr: 1.1mg/kgwith an analgesic or hypnotic at low dose | SEDATION PO/IV/IM/RECTAL Adult 12.5-50mg/dose Child 0.5-1mg/kg/dose q6h if needed, max 50mg/dose

Contra: Hypersensitivity, coma, asthma, LRTI treatment, children, intra-arterial/SC administration

Precautions: Bone marrow suppression, myasthenia gravis, glaucoma, parkinson’s disease, respiratory disease, CVD, seizures, tranquilizers, prostatic hypertrophy, pyloroduodenal, barbiturates, general anesthesia

ADR: Serious: bradycardia, hyper/hypotension, Nonspecific QT changes, postural hypotension, tinnitus, blurred vision, asthma, gynecomastia, thrombophlebitis, tissue necrosis, NMS, extrapyramidal symptoms, respiratory depression, impotence, amenorrhea, Others: corneal & lenticular changes, urinary retention, blood disorders, urticaria, akathisia, confusion, delirium, disorientation, drowsiness, dystonia, euphoria, excitation, faintness, fatigue, hallucinations, insomnia, nightmares, dyskinesia, sedation, xerostomia, ejaculatory disorder, nausea, vomiting, nasal congestion, hyperglycemia

DDI: Serious Chloroquine (IM) level increases, CNS Depressants causes additive CNS depression, Pethidine increases respiratory depression, sedation, CNS toxicity & hypotension

Diet: With/without food

Monitor: Signs and symptoms of neuroleptic malignant syndrome, adverse CNS effects,CBC & LFT

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