Propafenone

Details About Generic Salt ::  Propafenone 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Arrhythmics

4B. ANTI-ARRHYTHMICS in 4. CARDIOVASCULAR SYSTEM
PROPAFENONE
DIRECT MEMBRANE STABILIZER | ANTI-ARRHYTHMIC
PK: A: Well absorbed D: 2-5 L/kg (Vd in Adults) M: Hepatic

Indications & Dose: VENTRICULAR ARRHYTHMIAS PO Adult IR tablet: Initially 150mg TID, increase at 3-4day intervals, max 300mg TID, ER tablet: Initially 225mg BID, dosage increase may be made at minimum of 5 days interval. If required may further increase to 325mg BID max 425mg BID

Contra: Hypersensitivity, uncontrolled HF, SA, AV & intraventricular disorders of impulse generation and/or conduction, sinus bradycardia, cardiogenic shock, hypotension, bronchospastic disorders, uncorrected electrolyte abnormalities, concurrent use of ritonavir

Precautions: QT interval prolongers, myasthenia gravis, HF, hepatic impairment, electrolyte disturbances

ADR: Serious: Arrhythmia, CHF, lupus-like syndrome, myasthenia gravis, seizures, agranulocytosis, ventricular tachycardia, palpitation, syncope, intraventricular conduction delay, blurred vision, tremor, arthralgia, Others: dizziness, altered taste, nausea, vomiting, constipation, headache, fatigue, diaphoresis, dyspnea

DDI: Serious Warfarin efficacy is increased, Fluoxetine/Erythromycin/HIV protease inhibitors/Paroxetine/Quinidine increases drug level, Metoprolol/Digoxin/Propranolol levels are increased, Rifampicin/Phenobarbital reduces drug level

Diet: With/without food

Monitor: BP, PR, ECG, CHF & anemia symptoms,CBC

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